{"title":"miRNA mediated gene regulatory network analysis of Cichorium intybus (chicory)","authors":"Swati Srivastava, Noopur Singh, Gaurava Srivastava, Ashok Sharma","doi":"10.1016/j.aggene.2016.11.003","DOIUrl":null,"url":null,"abstract":"<div><p><span><em>Cichorium intybus</em></span><span> commonly known as chicory, is an important medicinal plants<span> having different therapeutic properties. Several studies have been done on plant miRNAs for understanding their role in biological functions. However, no miRNAs are reported in miRBase for the genus </span></span><em>C. intybus</em>. In the present study, we used a homology based search and <em>in-silico</em><span> approach for identifying miRNA in </span><em>C. intybus</em><span>. Twenty eight potential miRNA families were predicted. Out of 28 predicted miRNA families, 17 were found to regulate 349 target transcripts and play important role in different biological, cellular and metabolic process. To understand the miRNA mediated gene regulatory control and to validate predicted miRNA targets, a biological network was also constructed. Further study of </span><em>C. intybus</em> miRNA regulation mechanisms may help us to know more about the important roles of miRNAs in <em>C. intybus</em>.</p></div>","PeriodicalId":37751,"journal":{"name":"Agri Gene","volume":"3 ","pages":"Pages 37-45"},"PeriodicalIF":0.0000,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.aggene.2016.11.003","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Agri Gene","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352215116300460","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 9
Abstract
Cichorium intybus commonly known as chicory, is an important medicinal plants having different therapeutic properties. Several studies have been done on plant miRNAs for understanding their role in biological functions. However, no miRNAs are reported in miRBase for the genus C. intybus. In the present study, we used a homology based search and in-silico approach for identifying miRNA in C. intybus. Twenty eight potential miRNA families were predicted. Out of 28 predicted miRNA families, 17 were found to regulate 349 target transcripts and play important role in different biological, cellular and metabolic process. To understand the miRNA mediated gene regulatory control and to validate predicted miRNA targets, a biological network was also constructed. Further study of C. intybus miRNA regulation mechanisms may help us to know more about the important roles of miRNAs in C. intybus.
Agri GeneAgricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)
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期刊介绍：
Agri Gene publishes papers that focus on the regulation, expression, function and evolution of genes in crop plants, farm animals, and agriculturally important insects and microorganisms. Agri Gene strives to be a diverse journal and topics in multiple fields will be considered for publication so long as their main focus is on agriculturally important organisms (plants, animals, insects, or microorganisms). Although not limited to the following, some examples of potential topics include: Gene discovery and characterization. Genetic markers to guide traditional breeding. Genetic effects of transposable elements. Evolutionary genetics, molecular evolution, population genetics, and phylogenetics. Profiling of gene expression and genetic variation. Biotechnology and crop or livestock improvement. Genetic improvement of biological control microorganisms. Genetic control of secondary metabolic pathways and metabolic enzymes of crop pathogens. Transcription analysis of beneficial or pest insect developmental stages Agri Gene encourages submission of novel manuscripts that present a reasonable level of analysis, functional relevance and/or mechanistic insight. Agri Gene also welcomes papers that have predominantly a descriptive component but improve the essential basis of knowledge for subsequent functional studies, or which provide important confirmation of recently published discoveries provided that the information is new.
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