Gastric Cancer: A review of risk factors and new insights into treatment

Abstract

Gastric cancer (GC) is one of the most frequent cancers in the world, whereas is ranked as the 4th most prevalent cancer and the second important reason of cancer death. Regrettably, GC is often diagnosed at a progressive phase; whereas the majority of patients are not having qualification for the remedial therapies in this stage. In addition, existing systemic chemotherapy exhibit the low efficiency and minimum survival profits. Now, GC therapy is multidisciplinary, and multiple option strategies are well-known; therefore, the present study reviewed the new insight into chemotherapy agents and various alternative and complementary strategies such as neoadjuvant &Adjuvant therapy, nanotherapy, natural medicines, etc. which are suggested for GC treatment. Moreover, we reviewed the current surgery techniques such as endoscopic resection, laparoscopic resection. We also summarized new insights into pathophysiology, epidemiology, risk factors, diagnosis, prevention and screening approaches in the GC.