Diphenyl ethers: Isolation, Bioactivities and Biosynthesis

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC Mini-reviews in Organic Chemistry Pub Date : 2023-07-07 DOI:10.2174/1570193x20666230707140919
Ning Chen, Bing-jing Liu, Yuxin Wang, Chenxue Li, Jintong Zhao, Ting Li
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Abstract

Diphenyl ethers (DPEs) are mainly produced by microorganisms and plants. The chemical structure of DPEs is relatively simple, and all of these compounds have the structure of biphenyl ethers in their chemical structure, the difference being the difference in the substituents on the benzene ring. Several recent studies have shown antibacterial, antioxidant, antitumor, antitumor, antihemolytic, neuroprotective, and anti-Alzheimer effects. DPEs could be candidate compounds for the treatment of Alzheimer's disease, by inhibiting the aggregation of Aβ42. Many DPEs from natural products exhibit good biological activity and they play an important role in the control of microbial infections. Diphenyl ethers have a wide range of applications and research value in the fields of pesticides, pharmaceuticals, textiles, household products, and public health. In this paper, we review the research progress of diphenyl ethers isolated from marine and plant endophytic sources in recent years, including their biosynthesis, and lay the foundation for further utilization and development.
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二苯醚类化合物的分离、生物活性和生物合成
二苯醚主要由微生物和植物产生。dpe的化学结构比较简单,这些化合物在化学结构上都具有联苯醚的结构,区别在于苯环上取代基的不同。最近的几项研究显示了抗菌、抗氧化、抗肿瘤、抗溶血、神经保护和抗阿尔茨海默病的作用。DPEs可以通过抑制a - β42的聚集而成为治疗阿尔茨海默病的候选化合物。许多天然产物的dpe具有良好的生物活性,在控制微生物感染方面发挥着重要作用。二苯醚在农药、医药、纺织、家居用品、公共卫生等领域有着广泛的应用和研究价值。本文综述了近年来从海洋和植物内生源分离的二苯醚及其生物合成的研究进展,为进一步利用和开发二苯醚奠定基础。
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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