Antioxidant Potential of Caesalpenia Bonducella Seeds in the Management of Polycystic Ovary Syndrome (PCOS) Using Mifepristone Induced Rats Model

Abstract

ABSTRACT The effects of ethanolic seed extract of Caesalpenia bonducella (ESECB) on in vivo enzymatic and non-enzymatic antioxidant levels and histopathological changes in Mifepristone-induced polycystic ovary syndrome (PCOS) female rats were evaluated. PCOS-induced rats were treated with ESECB at 200 mg and 400 mg kg−1 b.w. p.o. for 28 d. Metformin 20 mg kg−1 b.w. was used as a standard drug. At the end of the experimental period, blood was collected from all rats for the estimation of enzymatic and non-enzymatic antioxidants. Ovaries were used for the histopathological analysis. In rats treated with Mifepristone, there was a decrease in the antioxidant enzymes catalase, super oxide dismutase, glutathione peroxidase, glutathione – S – transferase and glutathione reductase, which increased in the ESECB-treated groups. The altered levels of non-enzymatic antioxidants were also brought back to normal levels in these groups. Histopathology showed that the ESECB-treated rats regained normal physiology of ovarian architecture, which was distorted due to the PCOS condition.