{"title":"Advances in pathological researches of free-heme","authors":"Xin Wei, Yaomei Wang, Xiaoli Qu, Jianjun Yang, Wei Zhang","doi":"10.3760/CMA.J.ISSN.1673-419X.2019.03.014","DOIUrl":null,"url":null,"abstract":"Heme is not only the coenzyme of hemoglobin(Hb), but also the coenzyme of myoglobin, cytochrome and peroxidase. It plays an important role in oxygen binding, electron transmission and signal transduction. However, free-heme is the metabolite of erythrocyte rupture, which is easy to penetrate the cell membrane and induce oxidative stress injury to tissues and cells. Many studies have found that the pathological processes of many diseases and organ injuries involve the toxic effects of free-heme, including immunity and inflammation, transfusion-related diseases, atherosclerosis, heart, brain, liver and kidney organ damage, etc.. This article reviews the current research progress in the pathological process of free-heme related diseases. \n \n \nKey words: \nHeme; Hemolysis; Erythrocytes; Oxidative stress; Pathologic processes","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"42 1","pages":"254-258"},"PeriodicalIF":0.0000,"publicationDate":"2019-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.03.014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Heme is not only the coenzyme of hemoglobin(Hb), but also the coenzyme of myoglobin, cytochrome and peroxidase. It plays an important role in oxygen binding, electron transmission and signal transduction. However, free-heme is the metabolite of erythrocyte rupture, which is easy to penetrate the cell membrane and induce oxidative stress injury to tissues and cells. Many studies have found that the pathological processes of many diseases and organ injuries involve the toxic effects of free-heme, including immunity and inflammation, transfusion-related diseases, atherosclerosis, heart, brain, liver and kidney organ damage, etc.. This article reviews the current research progress in the pathological process of free-heme related diseases.
Key words:
Heme; Hemolysis; Erythrocytes; Oxidative stress; Pathologic processes
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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