Jinshen Wang, Chun-qing Bu, Yanyan Wang, Haiyan Ye, Yue Han, Daogang Qin
{"title":"Effects of Garlicin on Proliferation and Differentiation of HL-60 Cells","authors":"Jinshen Wang, Chun-qing Bu, Yanyan Wang, Haiyan Ye, Yue Han, Daogang Qin","doi":"10.37290/ctnr2641-452x.21:109-116","DOIUrl":null,"url":null,"abstract":"We have explored the effect of garlicin, a biologically active compound isolated from garlic, on the proliferation and differentiation of HL-60 leukemia cells. To this end, we measured the effect of garlicin on cell proliferation, cell morphology, cell cycle, and the expression cluster of differentiation molecules 11b and 15, B-cell lymphoma 2 protein, and BCL2-associated X proteins. All-trans retinoic acid and arsenic trioxide treatments served as positive controls for comparison. Results show that garlicin significantly inhibited the proliferation of HL-60 cells and blocked most cells in the G0/G1 phase, with an effect stronger than all-trans retinoic acid or arsenic trioxide treatments. The ability to induce cell maturation and differentiation was like that of all-trans retinoic acid, which may play a role by downregulating the expression of B-cell lymphoma 2 protein and upregulating the expression of BCL2-associated X protein. In conclusion, garlicin significantly inhibits the proliferation and induces differentiation of HL-60 cells, and thus it may become a new clinically viable differentiation-inducing agent.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Topics in Nutraceutical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.37290/ctnr2641-452x.21:109-116","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
Abstract
We have explored the effect of garlicin, a biologically active compound isolated from garlic, on the proliferation and differentiation of HL-60 leukemia cells. To this end, we measured the effect of garlicin on cell proliferation, cell morphology, cell cycle, and the expression cluster of differentiation molecules 11b and 15, B-cell lymphoma 2 protein, and BCL2-associated X proteins. All-trans retinoic acid and arsenic trioxide treatments served as positive controls for comparison. Results show that garlicin significantly inhibited the proliferation of HL-60 cells and blocked most cells in the G0/G1 phase, with an effect stronger than all-trans retinoic acid or arsenic trioxide treatments. The ability to induce cell maturation and differentiation was like that of all-trans retinoic acid, which may play a role by downregulating the expression of B-cell lymphoma 2 protein and upregulating the expression of BCL2-associated X protein. In conclusion, garlicin significantly inhibits the proliferation and induces differentiation of HL-60 cells, and thus it may become a new clinically viable differentiation-inducing agent.
期刊介绍：
Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products.
To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine.
The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
