{"title":"Research progress of pathogenesis in polycythemia vera","authors":"Lixia Fu, Yingshao Wang","doi":"10.3760/CMA.J.ISSN.1673-419X.2018.06.010","DOIUrl":null,"url":null,"abstract":"Polycythemia vera (PV) is representative in Ph- myeloproliferative neoplasm (MPN), which is characterized by increasing of two or three line blood cells, especially erythrocytosis. First, during the occurrence and progression of PV, JAK2, TET2, IDH1/2 and ASXL1 gene mutation and associated epigenetic changes play an important role. Besides, abnormal cytokines produced by chronic inflammation can promote the malignant transformation of hematopoietic stem cells (HSC), which may also be one of the important mechanisms of PV occurrence. Moreover, the changes in hematopoietic microenvironment were also associated with the progression of post-PV myelofibrosis(MF). This article reviews the pathogenesis of PV from several aspects that involve genes mutation, chronic inflammation and the changing of hematopoietic microenvironment. \n \n \nKey words: \nPolycythemia vera; Hematopoietic stem cells; Mutation; Cytokines; Tumor microenvironment","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"41 1","pages":"515-519"},"PeriodicalIF":0.0000,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2018.06.010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Polycythemia vera (PV) is representative in Ph- myeloproliferative neoplasm (MPN), which is characterized by increasing of two or three line blood cells, especially erythrocytosis. First, during the occurrence and progression of PV, JAK2, TET2, IDH1/2 and ASXL1 gene mutation and associated epigenetic changes play an important role. Besides, abnormal cytokines produced by chronic inflammation can promote the malignant transformation of hematopoietic stem cells (HSC), which may also be one of the important mechanisms of PV occurrence. Moreover, the changes in hematopoietic microenvironment were also associated with the progression of post-PV myelofibrosis(MF). This article reviews the pathogenesis of PV from several aspects that involve genes mutation, chronic inflammation and the changing of hematopoietic microenvironment.
Key words:
Polycythemia vera; Hematopoietic stem cells; Mutation; Cytokines; Tumor microenvironment
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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