{"title":"Research progress on hepcidin and its related regulatory drugs","authors":"Yingying Chen, Lihong Wang","doi":"10.3760/CMA.J.ISSN.1673-419X.2019.01.014","DOIUrl":null,"url":null,"abstract":"Iron is the most basic element involved in oxygen transport, cell respiration, DNA replication, and other disorders of iron metabolism associated with a variety of diseases, including anemia (iron deficiency anemia, chronic anemia) and iron overload (hemochromatosis). Hepcidin is a small molecule peptide hormone synthesized by the liver, which plays a negative role in regulating iron metabolism and is particularly important for maintaining iron balance. Hepcidin is encoded by Hamp gene, and its expression is regulated by multiple signaling pathways such as BMP and STAT. Signal molecules such as interleukin (IL)-6 and transmembrane serine protease (TMPRSS)6 also play important roles in the regulation of hepcidin. This article reviews the molecular structure and role of hepcidin, as well as the current research progress on regulatory drugs targeting hepcidin, Hamp gene and its related signaling pathways. \n \n \nKey words: \nIron; Iron metabolism disorders; Hemochromatosis; Interleukin-6; Hepcidin; Hamp gene","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"42 1","pages":"85-89"},"PeriodicalIF":0.0000,"publicationDate":"2019-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.01.014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Iron is the most basic element involved in oxygen transport, cell respiration, DNA replication, and other disorders of iron metabolism associated with a variety of diseases, including anemia (iron deficiency anemia, chronic anemia) and iron overload (hemochromatosis). Hepcidin is a small molecule peptide hormone synthesized by the liver, which plays a negative role in regulating iron metabolism and is particularly important for maintaining iron balance. Hepcidin is encoded by Hamp gene, and its expression is regulated by multiple signaling pathways such as BMP and STAT. Signal molecules such as interleukin (IL)-6 and transmembrane serine protease (TMPRSS)6 also play important roles in the regulation of hepcidin. This article reviews the molecular structure and role of hepcidin, as well as the current research progress on regulatory drugs targeting hepcidin, Hamp gene and its related signaling pathways.
Key words:
Iron; Iron metabolism disorders; Hemochromatosis; Interleukin-6; Hepcidin; Hamp gene
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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