Sex difference in the association between pyrethroids exposure and sleep problems among adolescents: NHANES 2007–2014

IF 5.9 3区环境科学与生态学 Q1 Environmental Science Environmental Sciences Europe Pub Date : 2023-07-17 DOI:10.1186/s12302-023-00753-0

Long Zhou, Guangzhen Li, Xia Chen, Lei Zuo, Mingliang Liu, Chunxia Jing, Li Chen, Haiyan Chen, Sihui Peng, Guang Hao

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Abstract

Background

Pyrethroids have been widely used in the United States and worldwide. Few studies examined the effect of pyrethroids exposure on sleep problems among adolescents.

Objectives

This study investigated the associations between pyrethroids exposure and sleep problems in male and female adolescents.

Methods

The data were used from the National Health and Nutrition Examination Survey 2007–2014. In this study, 3-Phenoxybenzoic Acid (3-PBA) was used as a validated biomarker for pyrethroids exposure. The association between urinary 3-PBA and sleep problems was analyzed using logistic regression models.

Results

A total of 805 adolescents aged 16–20 years old were included in this study. The proportion of sleep problems was higher in females than in males (10.18% vs.7.35%, P = 0.154). A significant interaction was found between sex and 3-PBA (P interaction = 0.021) in the risk of sleep problems. A positive association of 3-PBA exposure with sleep problems was observed in male adolescents after adjusting for all the other covariates (OR = 4.04, 95% CI 1.31, 12.42). No statistically significant association was observed in female adolescents.

Conclusions

A positive association was observed between pyrethroids exposure and sleep problems in male adolescents, but not in female adolescents. More studies are required to confirm our findings.

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青少年接触拟除虫菊酯与睡眠问题之间的性别差异:NHANES 2007-2014

拟除虫菊酯在美国和世界范围内被广泛使用。很少有研究调查了接触拟除虫菊酯对青少年睡眠问题的影响。目的研究拟除虫菊酯类杀虫剂与青少年睡眠问题的关系。方法数据来源于2007-2014年全国健康与营养检查调查。在本研究中，3-苯氧苯甲酸(3-PBA)被用作拟除虫菊酯暴露的有效生物标志物。采用logistic回归模型分析尿3-PBA与睡眠问题的关系。结果共纳入16 ~ 20岁青少年805人。女性出现睡眠问题的比例高于男性(10.18% vs.7.35%， P = 0.154)。研究发现，性别与3-PBA之间存在显著的交互作用(P交互作用= 0.021)。在校正所有其他协变量后，在男性青少年中观察到3-PBA暴露与睡眠问题呈正相关(OR = 4.04, 95% CI 1.31, 12.42)。在女性青少年中没有观察到统计学上显著的关联。结论男性青少年接触拟除虫菊酯类杀虫剂与睡眠问题呈正相关，而女性青少年接触拟除虫菊酯类杀虫剂与睡眠问题无关。需要更多的研究来证实我们的发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Sciences Europe Environmental Science-Pollution

CiteScore

9.20

自引率

1.70%

发文量

110

审稿时长

13 weeks

期刊介绍： ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation. ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation. ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation. Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues. Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.