Methanol extract of Peltophorum Pterocarpum stem bark modulates Plasmodium berghei ANKA 65-Induced hypoglycemia and lipid dysfunction in Mice

Abstract

ABSTRACT This study evaluated the effects of methanol extract of Peltophorum pterocarpum stem bark (MEPTS) on blood glucose level and lipid profile of Plasmodium berghei ANKA 65-parasitized mice. The levels of total cholesterol (TC), low- and high-density lipoproteins (LDL and HDL, respectively), triacylglycerols (TAG) and blood glucose in parasitized mice treated with MEPTS (100, 200 or 400 mg kg−1 b.w. d−1, p.o) and artemether/lumenfantrin (28 mg kg−1 b.w. d−1, p.o) were determined and compared with malaria control. Alkaloids, saponins, flavonoids, tannins, glycosides, steroids, carotenoids, anthocyanins, anthraquinones, terpenoids, and phenols were detected in the extract. On days 1, 2, and 3, there were progressive increase in malaria parasitemia in malaria control compared with parasitized-MEPTS-administered mice that had dose-dependent decrease in malaria parasitemia. Malaria control group showed hyperlipidemia and hypoglycemia compared to normal mice, which was ameliorated by the administration of MEPTS, and artemether/lumenfantrin. These findings suggest that MEPTS may have potent antimalarial activity and modulated lipid dysfunction and hypoglycemia generated by malaria.