A review on the experimental role of platelet-rich plasma as a biological stimulator for cartilage regeneration

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL Journal of the Scientific Society Pub Date : 2023-05-01 DOI:10.4103/jss.jss_106_22
Kuldeep Chhatbar
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Abstract

Platelet-rich plasma (PRP) is a highly enriched combination of growth factors and pro-inflammatory cytokines which has shown success in cartilage healing. Furthermore, the fibrinogen in PRP may be triggered to produce a fibrin matrix to fill articular defects, so satisfying the basic needs of biological wound repair. The proliferative, anti-inflammatory, and scaffolding properties of PRP are discussed in this article obtained from laboratory experiments, observational studies, and clinical testing. PRP has been seen in culture to boost cell growth and calcareous matrix formation by osteocytes and mature mesenchymal stem cells (MSCs), promote matrix release by synoviocytes, reduce interleukin-1-induced inflammatory, and offer a favorable platform for MSCs. PRP has been utilized in preclinical trials as a hydrogel to fill cartilage deficiencies with varying results, or to stop the course of disease in animal models with beneficial results. Existing medical study findings indicate that PRP may have the capacity to fill tissue defects to promote cartilage regeneration, alleviate arthritis symptoms, and boost joint mobility while maintaining a reasonable safety profile. Despite the fact that current data indicates to prefer PRP above hyaluronan for the management of pain, the effectiveness of PRP therapies is undetermined due to the very diverse character of published research and the varying content of PRP formulations. Future research will be needed to identify the functional group actions of specific PRP components in modifying certain disease pathways.
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富血小板血浆作为软骨再生生物刺激剂的实验研究进展
富血小板血浆(PRP)是一种高度富集的生长因子和促炎细胞因子的组合,在软骨愈合中显示出成功。此外,PRP中的纤维蛋白原可能被触发产生纤维蛋白基质来填补关节缺损,从而满足生物创面修复的基本需要。本文从实验室实验、观察性研究和临床试验中讨论了PRP的增殖、抗炎和支架特性。PRP已在培养中被发现促进骨细胞和成熟间充质干细胞(MSCs)的细胞生长和钙基质形成,促进滑膜细胞释放基质,减少白细胞介素-1诱导的炎症,并为MSCs的形成提供有利的平台。在临床前试验中,PRP已被用作水凝胶来填补软骨缺陷,结果不同,或在动物模型中停止疾病进程,结果有益。现有的医学研究结果表明,PRP可能具有填补组织缺陷、促进软骨再生、缓解关节炎症状和增强关节活动能力的能力,同时保持合理的安全性。尽管目前的数据表明,在治疗疼痛方面,PRP比透明质酸更受青睐,但由于已发表研究的多样性和PRP配方的不同内容,PRP治疗的有效性尚不确定。未来的研究将需要确定特定PRP成分在改变某些疾病途径中的功能群作用。
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来源期刊
Journal of the Scientific Society
Journal of the Scientific Society MEDICINE, GENERAL & INTERNAL-
自引率
33.30%
发文量
19
审稿时长
36 weeks
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