Synapsis Expression Increased By Mozart’s Music Stimulation Compared With Indonesian Pop And Religious Music

Ukhti Mukminah Ilmi Amila, H. T. Joewono, W. Widjiati
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Abstract

Classical music stimulation is a proven method that affect intelligence as well as brain function. Mozart’s classical music is classical music that could stimulate the growth of synaptic networks. To analyze the difference of synapsin expression of the brain of Rattus norvegicus  offspring on Mozart’s, pop, religious and without music stimulation during pregnancy. Experimental. Treatments were subjected to Rattus norvegicusas a subject organism, initiated on the 10th day of pregnancy, in 1 hour duration in a soundproof chamber, intensity of 65 dB. On the 19th day of pregnancy the subjects were sacrificed and three offsprings were chosen. The head of the chosen Rattus norvegicusoffsprings were decapitated and the brain subsequently sectioned to calculate synapsin expression by immunohistochemistry method with 400 magnification strength microscope on the 5 field of view. Significant difference of synapsin expression of the brain of Rattus norvegicus offspring was observed between Mozart’s and control group. Significant differences of synapsin expressions were observed in the cerebellum of the newly born Rattus novergicus between Mozart and pop music groups (p = 0,007), Mozart and religious music groups (p = 0,008), Mozart and without music groups (p = 0,004).Synapsin expression of Rattus norvegicus brain offsprings were higher in Mozart music stimulation compared with pop and religious music stimulation
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与印尼流行音乐和宗教音乐相比,莫扎特音乐刺激下突触表达增加
古典音乐刺激是一种行之有效的影响智力和大脑功能的方法。莫扎特的古典音乐是能够刺激突触网络生长的古典音乐。分析褐家鼠后代在怀孕期间接受莫扎特音乐、流行音乐、宗教音乐和无音乐刺激时大脑突触蛋白表达的差异。实验的对受试生物褐家鼠进行治疗,于妊娠第10天开始,在隔音室中持续1小时,强度为65dB。在妊娠第19天,处死受试者并选择三个后代。将所选的褐家鼠的头部斩首,随后通过免疫组织化学方法在5视野上用400倍放大强度显微镜对大脑进行切片以计算突触蛋白酶的表达。莫扎特实验组与对照组相比,褐家鼠子代大脑突触蛋白表达有显著差异。莫扎特与流行音乐组(p=0.007)、莫扎特与宗教音乐组(p=0.008)、莫扎特和无音乐组(p=0004)在新生新鼠小脑中观察到突触蛋白表达的显著差异。与流行音乐和宗教音乐刺激相比,莫扎特音乐刺激下褐家鼠大脑子代突触蛋白表达更高
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