{"title":"Microphysiological systems in the evaluation of hematotoxicities during drug development","authors":"Eva-Maria Dehne, Annika Winter, Uwe Marx","doi":"10.1016/j.cotox.2019.09.008","DOIUrl":null,"url":null,"abstract":"<div><p><span>Microphysiological systems are progressively entering the pharmaceutical industry, and various systems have already proven to be highly valuable at different stages of the drug development<span> process. The field of hematotoxicity research has so far received only minor attention, even though microphysiological systems might provide key benefits over current assays. In this review, we will highlight the need for more complex human </span></span><em>in vitro</em> assays, and how emerging technologies such as microphysiological systems present novel solutions for the study of adverse hematologic effects.</p></div>","PeriodicalId":37736,"journal":{"name":"Current Opinion in Toxicology","volume":"17 ","pages":"Pages 18-22"},"PeriodicalIF":3.6000,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cotox.2019.09.008","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468202019300014","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 4
Abstract
Microphysiological systems are progressively entering the pharmaceutical industry, and various systems have already proven to be highly valuable at different stages of the drug development process. The field of hematotoxicity research has so far received only minor attention, even though microphysiological systems might provide key benefits over current assays. In this review, we will highlight the need for more complex human in vitro assays, and how emerging technologies such as microphysiological systems present novel solutions for the study of adverse hematologic effects.
期刊介绍：
The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.
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