Joshua P. Sasine, Thomas D Lee, Rena R. Xian, G. Schiller
{"title":"Acute Myeloid Leukemia with Cup-Like Nuclear Inclusions, and FLT3-ITD andNPM1 Mutations","authors":"Joshua P. Sasine, Thomas D Lee, Rena R. Xian, G. Schiller","doi":"10.4172/2329-6917.1000I101","DOIUrl":null,"url":null,"abstract":"A 69-year-old man presented to an outside hospital with fatigue, fevers, altered mental status, and dyspnea. Laboratory testing revealed a white blood cell count of 231 × 103/μL with 88% blasts, hemoglobin of 6.2 g/dL, and platelet count of 80 × 103/μL. Bone marrow biopsy confirmed a diagnosis of acute myeloid leukemia (AML) with flow cytometric analysis demonstrating two abnormal myeloblast populations, the first expressing CD11b (partial), CD13, CD33, CD45 (dim), CD64, CD117, and HLA-DR and the other CD10, CD11b, CD13 (subset), CD14, CD15, CD33, CD45 (moderate to bright), CD64, and HLA-DR. Both populations showed heterogeneous expression of myeloperoxidase and were negative for CD34 expression. Karyotype and FISH studies revealed no chromosomal abnormalities.","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of leukemia (Los Angeles, Calif.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2329-6917.1000I101","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A 69-year-old man presented to an outside hospital with fatigue, fevers, altered mental status, and dyspnea. Laboratory testing revealed a white blood cell count of 231 × 103/μL with 88% blasts, hemoglobin of 6.2 g/dL, and platelet count of 80 × 103/μL. Bone marrow biopsy confirmed a diagnosis of acute myeloid leukemia (AML) with flow cytometric analysis demonstrating two abnormal myeloblast populations, the first expressing CD11b (partial), CD13, CD33, CD45 (dim), CD64, CD117, and HLA-DR and the other CD10, CD11b, CD13 (subset), CD14, CD15, CD33, CD45 (moderate to bright), CD64, and HLA-DR. Both populations showed heterogeneous expression of myeloperoxidase and were negative for CD34 expression. Karyotype and FISH studies revealed no chromosomal abnormalities.
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