Pub Date : 2021-01-01DOI: 10.35248/2329-6917.21.9.271
M. Aznag, A. Raissi, H. Yahyaoui, M. Chakour, Mohamed Amine Haouane, M. A. Ameur
Autoimmune hemolytic anemia occurring during the course of either sarcoidosis or tuberculosis is a rare phenomenon, but was already reported in the literature. The association of these three diseases is extremely rare and has never been reported before. Here we describe the case of a young woman with autoimmune hemolytic anemia, tuberculosis and sarcoidosis, and discuss the different diagnosis and management challenges.
{"title":"Sarcoidosis, Tuberculosis and Autoimmune Hemolytic Anemia: An Unusual Association!","authors":"M. Aznag, A. Raissi, H. Yahyaoui, M. Chakour, Mohamed Amine Haouane, M. A. Ameur","doi":"10.35248/2329-6917.21.9.271","DOIUrl":"https://doi.org/10.35248/2329-6917.21.9.271","url":null,"abstract":"Autoimmune hemolytic anemia occurring during the course of either sarcoidosis or tuberculosis is a rare phenomenon, but was already reported in the literature. The association of these three diseases is extremely rare and has never been reported before. Here we describe the case of a young woman with autoimmune hemolytic anemia, tuberculosis and sarcoidosis, and discuss the different diagnosis and management challenges.","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":"9 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69998923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6917.21.9.E110
F. Socola
{"title":"Know More about Leukemia","authors":"F. Socola","doi":"10.35248/2329-6917.21.9.E110","DOIUrl":"https://doi.org/10.35248/2329-6917.21.9.E110","url":null,"abstract":"","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":"9 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69999567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6917.21.9.E118
T. Tadmor
Although genetic testing is recommended for women with epithelial ovarian cancer (EOC), little is known about patient preferences for various testing options. We measured relative preferences for attributes of testing in women with EOC referred for genetic counseling. Low owed price, high chance of detection injurious mutations and high chance of a EOC result area unit most well-liked by patients with EOC considering genetic testing.
{"title":"Epithelial Ovarian Cancer in Women","authors":"T. Tadmor","doi":"10.35248/2329-6917.21.9.E118","DOIUrl":"https://doi.org/10.35248/2329-6917.21.9.E118","url":null,"abstract":"Although genetic testing is recommended for women with epithelial ovarian cancer (EOC), little is known about patient preferences for various testing options. We measured relative preferences for attributes of testing in women with EOC referred for genetic counseling. Low owed price, high chance of detection injurious mutations and high chance of a EOC result area unit most well-liked by patients with EOC considering genetic testing.","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":"9 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69999813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6917.21.9.262
Inoue Kato
{"title":"Brain Tumor Problem Phased by Humans","authors":"Inoue Kato","doi":"10.35248/2329-6917.21.9.262","DOIUrl":"https://doi.org/10.35248/2329-6917.21.9.262","url":null,"abstract":"","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":"9 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69998900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6917.21.9.E134
T. James
{"title":"Nursing Data-Based Clinical Test For Patients with Blood Cancer","authors":"T. James","doi":"10.35248/2329-6917.21.9.E134","DOIUrl":"https://doi.org/10.35248/2329-6917.21.9.E134","url":null,"abstract":"","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":"9 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70001192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6917.21.9.270
P. Mokarram, Parisa Alizadeh, S. Saeb, Nasim Rahmani-Kukia, M. Babazadeh, M. Siri
Background: In Multiple Sclerosis (MS) as the demyelination happens, Oligodendrocyte Precursor Cells (OPCs) migrate to the site of injury and start differentiating into mature oligodendrocytes to regenerate the myelin sheaths. This OPC differentiation process can be affected by the epigenetic mechanisms which are mediated by a family of DNA methyltransferases (DNMTs) such as DNMT3A and DNMT3B. However, Dietary factors can alter the DNMTs expressions and even their activities. Therefore, in this study the effect of dietary factors such as vitamin A and D on the expression of DNMT3A and DNMT3B genes was assessed during these cells. Methods: Rat embryonic stem cells were derived from ganglionic eminence. Then, the stem cells were cultured, differentiated and divided into five groups: control negative, control positive and three treatment modalities consist of vitamin D3, vitamin A, and vitamin A+D. Lastly, the Real-time PCR assay was conducted with total RNA. Results: The expression of DNMT3B gene was significantly different between the groups, especially in the groups treated with vitamin A. Conclusion: It seems that vitamin A can affect the expression of DNMT3B which plays a major role in cell differentiation and can be considered as a novel target for treatment of MS disease.
{"title":"Effects of Vitamin A and D on DNA Methyltransferases 3A and 3B Expression and Neural Stem Cell Differentiation","authors":"P. Mokarram, Parisa Alizadeh, S. Saeb, Nasim Rahmani-Kukia, M. Babazadeh, M. Siri","doi":"10.35248/2329-6917.21.9.270","DOIUrl":"https://doi.org/10.35248/2329-6917.21.9.270","url":null,"abstract":"Background: In Multiple Sclerosis (MS) as the demyelination happens, Oligodendrocyte Precursor Cells (OPCs) migrate to the site of injury and start differentiating into mature oligodendrocytes to regenerate the myelin sheaths. This OPC differentiation process can be affected by the epigenetic mechanisms which are mediated by a family of DNA methyltransferases (DNMTs) such as DNMT3A and DNMT3B. However, Dietary factors can alter the DNMTs expressions and even their activities. Therefore, in this study the effect of dietary factors such as vitamin A and D on the expression of DNMT3A and DNMT3B genes was assessed during these cells. Methods: Rat embryonic stem cells were derived from ganglionic eminence. Then, the stem cells were cultured, differentiated and divided into five groups: control negative, control positive and three treatment modalities consist of vitamin D3, vitamin A, and vitamin A+D. Lastly, the Real-time PCR assay was conducted with total RNA. Results: The expression of DNMT3B gene was significantly different between the groups, especially in the groups treated with vitamin A. Conclusion: It seems that vitamin A can affect the expression of DNMT3B which plays a major role in cell differentiation and can be considered as a novel target for treatment of MS disease.","PeriodicalId":90223,"journal":{"name":"Journal of leukemia (Los Angeles, Calif.)","volume":"9 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69998917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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