Correlation of the human papillomavirus infection status and genotyping with the result of liquid-based thin-layer cytology of cervix in the female physical examiners in Xi'an

Q4 Medicine 肿瘤研究与临床 Pub Date : 2019-11-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2019.11.001

Hongyun Chang, Xiaofeng Li, Yuanyuan Wang, P. Nan, Xiao-meng Zhao

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Abstract

Objective To investigate the correlation of human papillomavirus (HPV) infection status and genotyping characteristics with the result of liquid-based thin-layer cytology (TCT) of the cervix in the female physical examiners in Xi'an. Methods The data of 5 163 female physical examiners who underwent HPV and TCT screening simultaneously in the First Affiliated Hospital of Xi'an Jiaotong University From June 2017 to June 2018 were collected to analyze HPV infection, genotyping and their relationship with TCT. Results Among the 5 163 examiners, 527 (10.21%) were HPV-positive, and the infection rate in the examiners over 60 years old was the highest [12.26% (57/465)]. Among HPV-positive examiners, the infection rate of single genotype was higher than that of multiple genotypes infection [75.90% (400/527) vs. 24.10% (127/527), P 0.05]. Among 50 examiners with positive results of HPV and TCT tests, the top four genotypes were type 58, 52, 53 and 16, and they were in consistence with the overall HPV infection genotyping. Conclusions The HPV infection in the female physical examiners in Xi'an is dominated by the single genotype infection, and the main genotypes of HPV infection are type 52, 58, 53 and 16. The combined detection of HPV genotyping and TCT can improve the effectiveness of cervical lesions screening. Key words: Human papillomavirus; Genotype; Cervical intraepithelial neoplasia; Liquid-based cytology; Xi'an

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西安市女性体检者宫颈液基薄层细胞学检测结果与人乳头瘤病毒感染状况及分型的相关性

目的探讨西安市女性体检人员宫颈液体薄层细胞学检查结果与人乳头瘤病毒(HPV)感染状况及基因分型特征的相关性。方法收集2017年6月至2018年6月在西安交通大学第一附属医院同时进行HPV和TCT筛查的5 163名女性体检者的资料，分析HPV感染、基因分型及其与TCT的关系。结果5163名体检者中hpv阳性527人(10.21%)，其中60岁以上体检者感染率最高[12.26%(57/465)]。hpv阳性检出者中，单基因型感染率高于多基因型感染率[75.90%(400/527)比24.10% (127/527)，P < 0.05]。在50名HPV和TCT检测阳性的检查人员中，基因型最多的是58型、52型、53型和16型，与HPV感染总体基因分型一致。结论西安市女性体检人员HPV感染以单一基因型感染为主，主要基因型为52型、58型、53型和16型。HPV基因分型与TCT联合检测可提高宫颈病变筛查的有效性。关键词:人乳头瘤病毒;基因型;宫颈上皮内瘤变;液态细胞学;西安

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.