Current research status of prognostic scoring systems in primary myelofibrosis

Junying Wu
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Abstract

The clinical presentation and prognosis for patients with primary myelofibrosis (PMF) are of highly heterogeneous. Several risk stratification models are raised in order to stratify patients accurately and guide appropriate treatment decisions. Recently, the cytogenetic and molecular pathogenesis of patients with PMF have been elucidated considerably. Therefore, prognostic scoring systems are updating to improve prognostic effectiveness and guidance value for therapy decisions. This article summarizes the advances of prognostic factors, the advantages and disadvantages of different prognostic scoring systems and the practical usefulness of the prognostic scoring systems in terms of clinical decision making. Key words: Primary myelofibrosis; Myeloproliferative disorders; Myelofibrosis; Prognostic factors; Prognostic scoring systems; Genetics
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原发性骨髓纤维化预后评分系统的研究现状
原发性骨髓纤维化(PMF)患者的临床表现和预后具有高度异质性。为了准确地对患者进行分层并指导适当的治疗决策,提出了几个风险分层模型。近年来,PMF患者的细胞遗传学和分子发病机制已得到相当程度的阐明。因此,预后评分系统正在更新,以提高预后的有效性和对治疗决策的指导价值。本文综述了预后因素的进展、不同预后评分系统的优缺点以及预后评分系统在临床决策中的实用性。关键词:原发性骨髓纤维化;骨髓增生性疾病;骨髓纤维化;预后因素;预后评分系统;遗传学
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期刊介绍: The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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