Phytochemicals and biological activities of caraway (Carumcarvi L.) essential oil

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Egyptian Pharmaceutical Journal Pub Date : 2023-04-01 DOI:10.4103/epj.epj_154_22
M. El-Rady, N. Rasmy, N. Yasin, Hanea Fahmy, A. Amer
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Abstract

Background and aim Caraway is a famous medicinal plant in various pharmaceutical, food, and cosmetic industries. This study aimed to investigate the chemical composition, antioxidant, antimicrobial, and anticancer activities of this plant’s essential oil (EO). Materials and methods Caraway EO was obtained from dried caraway seeds using the hydrodistillation process. The composition of caraway EO was inspected by gas chromatography-mass spectrometry (GC–MS) analyses. The antioxidant activity of caraway EO was determined by three different in vitro antioxidant assays: 2,2-diphenylpicrylhydrazyl (DPPH•), 2,2’-azino-bis3-ethylbenzothiazoline-6-sulfonic acid (ABTS•+) scavenging activity and reducing power. The agar well diffusion method was used to assess the antimicrobial action. The cytotoxic activity was evaluated using the MTT (3-(4, 5-dimethyl thiazol-2yl)-2, 5-diphenyl tetrazolium bromide) assay, and the data were expressed as the half-maximal inhibitory concentration (IC50). Results and conclusion Carvone was the major compound of caraway EO, followed by limonene. Estimation of the antioxidant activity using DPPH• scavenging activity, ABTS•+ scavenging activity, and reducing power assays revealed effective efficacy [IC50=32.46±0.75, 2.44±0.44, and 17.65±0.70 µg/ml, respectively, compared with 11.55±0.53, 1.50±0.29, and 23.19±0.78 µg/ml for standard control (butylated hydroxyanisole), respectively]. Strong anticancer activity was detected against all types of cancer cells, especially the colon cell line (HCT-116) and liver cell line (HepG-2). These results suggest that caraway EO can be used as a preservative food agent in food industries as well as in the field of pharmacy, as it presents promising anticancer properties.
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香菜精油的植物化学成分及生物活性研究
背景和目的香菜是一种著名的药用植物,广泛应用于医药、食品和化妆品行业。本研究旨在研究该植物精油的化学成分、抗氧化、抗菌和抗癌活性。材料与方法采用加氢蒸馏法从香菜种子中提取香菜EO。通过气相色谱-质谱(GC–MS)分析检测了香菜EO的成分。通过三种不同的体外抗氧化试验测定了香菜EO的抗氧化活性:2,2-二苯基苦基肼(DPPH•)、2,2'-叠氮基双3-乙基苯并噻唑啉-6-磺酸(ABTS•+)的清除活性和还原力。采用琼脂扩散法评价其抗菌作用。使用MTT(3-(4,5-二甲基噻唑-2基)-2,5-二苯基四唑溴化)测定法评估细胞毒性活性,并将数据表示为半数最大抑制浓度(IC50)。结果与结论香菜EO的主要成分为香芹酮,其次为柠檬烯。使用DPPH•清除活性、ABTS•+清除活性和还原力测定法评估抗氧化活性显示出有效功效[IC50=32.46±0.75、2.44±0.44和17.65±0.70 µg/ml,而11.55±0.53、1.50±0.29和23.19±0.78 µg/ml用于标准对照(丁基羟基茴香醚)]。对所有类型的癌症细胞,特别是结肠细胞系(HCT-116)和肝细胞系(HepG-2),检测到强烈的抗癌活性。这些结果表明,香菜EO可作为食品防腐剂用于食品工业和制药领域,因为它具有良好的抗癌性能。
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来源期刊
Egyptian Pharmaceutical Journal
Egyptian Pharmaceutical Journal PHARMACOLOGY & PHARMACY-
CiteScore
1.10
自引率
0.00%
发文量
37
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