A Study of the Safety and Efficacy of Alternate Day vs. Daily Rosuvastatin Dosing in Hypercholesterolemia Patients at Tertiary Care Hospital

R. Yadav, Gaurav Chhetri
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Abstract

Background: Many of the patients with coronary heart disease require lifelong statin administration. Patients usually discontinue the medicine either due to side effects like myalgia, hepatotoxicity or due to the cost of the medicine.  The aim of this study is to see the scope of adjustment of the regimen to alternate-day dosing as an option to be considered in patients for whom adverse effects or cost are issues. Materials and Methods: A comparative, prospective, parallel group and open study was performed on forty- two patients of both genders with dyslipidaemia within the age group of 30 to 60 years attending the out – patients department of Medicine of Nobel Medical College and Teaching Hospital from February 2020 to March 2020. Mean reductions in different lipid fractions in the two treatment groups over the eight-week study period was calculated and then compared. Frequencies of patients developing different side effects was also calculated and compared between the two groups. Results: Baseline characters of both the groups were well balanced. Low density lipoprorein-C was reduced by 33.8 % in once-daily group and 31.3 % in alternate-day group, respectively. Changes were also recorded for the other lipid parameters. Such changes were found to be of no significant difference when compared between the two groups (p>0.05). Conclusion: An alternate-day regimen of statin in patients of hyperlipidaemia showed similar effect on the lipid panel compared to daily regimen.
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三级医院高胆固醇血症患者隔日与每日瑞舒伐他汀剂量的安全性和有效性研究
背景:许多冠心病患者需要终生服用他汀类药物。患者通常会因为肌痛、肝毒性等副作用或药物成本而停药。本研究的目的是将方案调整为隔日给药的范围作为不良反应或费用问题患者的一种选择。材料和方法:对2020年2月至2020年3月在诺贝尔医学院和教学医院门诊部就诊的42名30至60岁的两性血脂异常患者进行了一项比较、前瞻性、平行组和开放性研究。计算并比较两个治疗组在八周研究期间不同脂质组分的平均减少量。还计算了两组患者出现不同副作用的频率并进行了比较。结果:两组患者的基线特征平衡良好。低密度脂蛋白-C在每日一次组和隔日组分别降低了33.8%和31.3%。还记录了其他脂质参数的变化。结论:高脂血症患者他汀类药物的隔日方案与每日方案相比,对脂质组的影响相似。
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19
审稿时长
16 weeks
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