{"title":"Ameliorative Effect of Pongamia Pinnata on Histopathology of Vital Organs Involved in the Alloxan Induced Diabetic Rats","authors":"A. Morajkar, Bharatbhushan Sharma, Kiran R Kharat","doi":"10.1080/10496475.2022.2116623","DOIUrl":null,"url":null,"abstract":"ABSTRACT The ameliorative effect of aqueous (PPAqExt) and alcohol (PPAlcExt) extracts of Pongamia pinnata on degenerative histopathological changes in diabetic rats were investigated. Rats were divided into six groups. 1. Control group (NC). 2. Diabetic control group (DC)3. PPAqExt (TD1) 4. PPAlcExt (TD2) 5. Standard Control group (SD) 6. Vehicle Control group (VC). Blood samples were collected for the detection of Glycosylated Hemoglobin (HbA1c) levels. The vital organs pancreas, liver, kidney, and testis were prepared for histopathological studies. Treatment with PPAlcExt produced a reduction in HbA1c levels (8.4%) compared to DC (13.63%). The histopathological microscopic examination of diabetic rats showed marked changes in all the vital organs ranging from mild to severe along with cell infiltration, degeneration, and necrosis. Treatment with both the extracts showed a reversal in structural and cellular integrity of the vital organs involved in the pathophysiology of diabetes mellitus.","PeriodicalId":35803,"journal":{"name":"Journal of Herbs, Spices and Medicinal Plants","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Herbs, Spices and Medicinal Plants","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/10496475.2022.2116623","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
ABSTRACT The ameliorative effect of aqueous (PPAqExt) and alcohol (PPAlcExt) extracts of Pongamia pinnata on degenerative histopathological changes in diabetic rats were investigated. Rats were divided into six groups. 1. Control group (NC). 2. Diabetic control group (DC)3. PPAqExt (TD1) 4. PPAlcExt (TD2) 5. Standard Control group (SD) 6. Vehicle Control group (VC). Blood samples were collected for the detection of Glycosylated Hemoglobin (HbA1c) levels. The vital organs pancreas, liver, kidney, and testis were prepared for histopathological studies. Treatment with PPAlcExt produced a reduction in HbA1c levels (8.4%) compared to DC (13.63%). The histopathological microscopic examination of diabetic rats showed marked changes in all the vital organs ranging from mild to severe along with cell infiltration, degeneration, and necrosis. Treatment with both the extracts showed a reversal in structural and cellular integrity of the vital organs involved in the pathophysiology of diabetes mellitus.
期刊介绍：
The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.
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