{"title":"Current research status of diagnosis, treatment and prognostic factors of T-lymphoblastic lymphoma","authors":"Wen-FuThomas Lai","doi":"10.3760/CMA.J.ISSN.1673-419X.2019.04.009","DOIUrl":null,"url":null,"abstract":"T-lymphoblastic lymphoma(T-LBL) is a rare and highly aggressive lymphoma, with poor prognosis. It occurs mostly in children and male adolescents, and its main symptoms are mediastinal mass, lymphadenectasis, bone marrow invasion and central nervous system(CNS) invasion, etc.. The diagnosis of T-LBL is mainly based on lymph node biopsy, bone marrow cell morphology, immunology, cytogenetics and gene detection. After definitive diagnosis of T-LBL, the patients should be treated with extensive combined chemotherapy and sequential hematopoietic stem cell transplantation (HSCT) or maintenance treatment. There are many factors influencing the prognosis of T-LBL patients, such as age, bone marrow invasion, CNS invasion, disease stage and gene mutations. This article intends to introduce the development of diagnosis, therapy and prognostic factors of T-LBL to provide reference for the diagnosis and therapy of T-LBL. \n \n \nKey words: \nPrecursor T-cell lymphoblastic leukemia-lymphoma; Genetics; Immunology; Diagnosis; Therapy","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"42 1","pages":"332-337"},"PeriodicalIF":0.0000,"publicationDate":"2019-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.04.009","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
T-lymphoblastic lymphoma(T-LBL) is a rare and highly aggressive lymphoma, with poor prognosis. It occurs mostly in children and male adolescents, and its main symptoms are mediastinal mass, lymphadenectasis, bone marrow invasion and central nervous system(CNS) invasion, etc.. The diagnosis of T-LBL is mainly based on lymph node biopsy, bone marrow cell morphology, immunology, cytogenetics and gene detection. After definitive diagnosis of T-LBL, the patients should be treated with extensive combined chemotherapy and sequential hematopoietic stem cell transplantation (HSCT) or maintenance treatment. There are many factors influencing the prognosis of T-LBL patients, such as age, bone marrow invasion, CNS invasion, disease stage and gene mutations. This article intends to introduce the development of diagnosis, therapy and prognostic factors of T-LBL to provide reference for the diagnosis and therapy of T-LBL.
Key words:
Precursor T-cell lymphoblastic leukemia-lymphoma; Genetics; Immunology; Diagnosis; Therapy
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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