PREPARATION OF CRYSTALLINITY TAILORED SILK FIBROIN-SODIUM ALGINATE BASED FLOATING MICROBEADS FOR NEVIRAPINE DELIVERY

IF 1.3 4区农林科学 Q2 MATERIALS SCIENCE, PAPER & WOOD Cellulose Chemistry and Technology Pub Date : 2023-07-20 DOI:10.35812/cellulosechemtechnol.2023.57.47

Bhupesh DIGAMBAR PATIL, Sopan NAMDEV NANGARE, Laxmikant RAMVALLABH ZAWAR

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Abstract

The present work anticipated crystallinity-tuned silk fibroin (SFIB)-sodium alginate floating microbeads (MB) as a candidate for nevirapine (NEV) sustained release. Briefly, crystallinity tuning was accomplished using solvent annealing. The changes in structural conformation of SFIB were validated using FTIR spectroscopy. Here, the tangent baseline method revealed changes in crystallinity of floating NEV-loaded SFIB-MB. Importantly, solvent annealing offers conversion of amorphous ‘α-helix’ to crystalline ‘β-sheet’ of SFIB, helping to modify drug release from the matrix of SFIB-sodium alginate. As well, NEV-loaded SFIB-MB demonstrated good floating profile. The NEV-loaded SFIB-MB with ethanol (ETH-6) annealing for 6 hours shows 25.853% drug release at 12 hours (pH = 1.2), compared to untreated NEV-loaded SFIB-MB (65.132%, 12 hours, log p < 0.0001). The release kinetics of batch ETH-6 revealed first-order release kinetics and Fickian diffusion (n = 0.468) was found to be the drug diffusion mechanism. Therefore, crystallinity-modified floating NEV-loaded SFIB-based MB will open a new door for modified drug delivery.

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奈韦拉平载药用定制丝素-海藻酸钠漂浮微球的制备

本研究期望结晶调节丝素(SFIB)-海藻酸钠漂浮微珠(MB)作为奈韦拉平(NEV)缓释的候选材料。简单地说，结晶度调整是用溶剂退火完成的。利用FTIR光谱验证了SFIB结构构象的变化。在这里，切线基线法揭示了漂浮的nev负载的SFIB-MB结晶度的变化。重要的是，溶剂退火使SFIB的非晶“α-螺旋”转化为结晶“β-片”，有助于改变SFIB-海藻酸钠基质的药物释放。此外，nev加载的SFIB-MB显示出良好的浮动特性。nev负载的SFIB-MB经乙醇(ETH-6)退火6小时，在12小时(pH = 1.2)时，与未处理的nev负载SFIB-MB(65.132%， 12小时，log p < 0.0001)相比，药物释放量为25.853%。批ETH-6的释放动力学为一级释放动力学，Fickian扩散(n = 0.468)为药物扩散机制。因此，结晶修饰的漂浮nev负载sfib基MB将为修饰药物递送打开一扇新的大门。

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来源期刊

Cellulose Chemistry and Technology 工程技术-材料科学：纸与木材

CiteScore

2.30

自引率

23.10%

发文量

审稿时长

7.3 months

期刊介绍： Cellulose Chemistry and Technology covers the study and exploitation of the industrial applications of carbohydrate polymers in areas such as food, textiles, paper, wood, adhesives, pharmaceuticals, oil field applications and industrial chemistry. Topics include: • studies of structure and properties • biological and industrial development • analytical methods • chemical and microbiological modifications • interactions with other materials