{"title":"Association between Germline Mutations in the RET Proto-Oncogene and Colorectal Cancer and Polyps","authors":"R. Guy","doi":"10.19080/argh.2019.12.555835","DOIUrl":null,"url":null,"abstract":"The RET proto-oncogene is located on chromosome 10q11.2 and encodes a transmembrane receptor tyrosine kinase that has three unique isoforms [1]. Four ligands can bind and activate RET, leading to the aberrant activity of several signaling pathways including PI3K/Akt and MAPK pathway [2]. The aberrant expression of RET may function as an oncogene in certain solid tumor malignancies including papillary, medullary thyroid cancers and the multiple endocrine neoplasm type 2 (MEN2) syndrome [3,4].","PeriodicalId":72074,"journal":{"name":"Advanced research in gastroenterology & hepatology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced research in gastroenterology & hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.19080/argh.2019.12.555835","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The RET proto-oncogene is located on chromosome 10q11.2 and encodes a transmembrane receptor tyrosine kinase that has three unique isoforms [1]. Four ligands can bind and activate RET, leading to the aberrant activity of several signaling pathways including PI3K/Akt and MAPK pathway [2]. The aberrant expression of RET may function as an oncogene in certain solid tumor malignancies including papillary, medullary thyroid cancers and the multiple endocrine neoplasm type 2 (MEN2) syndrome [3,4].
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