Effect of Different Remineralization Agents on Artificial Caries Lesion: An in-vitro Study

IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Clinical and Experimental Health Sciences Pub Date : 2023-03-29 DOI:10.33808/clinexphealthsci.1103037
Ecem AKBEYAZ ŞİVET, Ayşe Nur PARLAKYILDIZ GÖKÇE, B. Kargul
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Abstract

Objective: Remineralization technologies have been shown to arrest or reverse early carious lesions. This study aimed to evaluate and compare the effect of different agents on enamel remineralization in-vitro. Methods: Thirty-five enamel blocks were prepared and divided into the following groups: Group 1; CaGp and Xylitol-containing gel (R.O.C.S Medical Mineral Gel), Group 2; 1100 ppm NaF and 10% CPP-ACP toothpaste (MI Paste One), Group 3; 0.45% SnF2-1150 ppm F toothpaste (Enamelon), Group 4; Positive Control-1450 ppm NaF toothpaste (Colgate Total) and Group 5; Negative Control (deionized water). Microhardness was measured at baseline, after demineralization, and after respective treatments for different treatment groups using a digital Micro Vickers Hardness Tester. For producing demineralized lesions, samples were stored in acidic hydroxyethylcellulose (HEC, pH=4.8) for three days. The Paired Sample t-test, one-way ANOVA, and Tukey were used to compare data and SMH recovery (%SMHR) calculated among treatments. Results: The mean baseline surface microhardness value was statistically non-significant between the groups (p=.378). CaGP and Xylitolcontaining gel demonstrated having the most protective effect against demineralization. The surface remineralization potential of 1100 ppm NaF and 10% CPP-ACP containing novel toothpaste (MI Paste One) was almost similar to the positive control (1450 ppm Fluoride toothpaste)group (p>.05). Conclusions: All treatment groups showed remineralization after respective treatments and these agents can be used as an effective preventive measure for pediatric patients.
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不同再矿化剂对人工龋齿损害的体外研究
目的:再矿化技术已被证明可以阻止或逆转早期龋齿病变。本研究旨在评价和比较不同药物对体外牙釉质再矿化的影响。方法:制备35个牙釉质块,分为1组;含CaGp和木糖醇凝胶(R.O.C.S医用矿物凝胶),第2组;1100 ppm NaF和10% CPP-ACP牙膏(MI Paste One),组3;0.45% SnF2-1150 ppm F牙膏(搪塞龙),第4组;阳性对照:1450 ppm含氟牙膏(高露洁Total)和第5组;阴性对照(去离子水)。使用数字显微维氏硬度计测量不同处理组在基线、脱矿后和各自处理后的显微硬度。为了产生脱矿病变,将样品保存在酸性羟乙基纤维素(HEC, pH=4.8)中三天。使用配对样本t检验、单因素方差分析和Tukey来比较数据和处理间计算的SMH回收率(%SMHR)。结果:各组平均基线表面显微硬度值差异无统计学意义(p=.378)。CaGP和木糖醇凝胶对脱矿的保护作用最强。含有1100 ppm NaF和10% CPP-ACP的新型牙膏(MI Paste One)的表面再矿化电位与阳性对照(1450 ppm氟化物牙膏)组几乎相似(p>.05)。结论:各治疗组治疗后均出现再矿化现象,这些药物可作为儿科患者的有效预防措施。
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Clinical and Experimental Health Sciences
Clinical and Experimental Health Sciences MEDICINE, RESEARCH & EXPERIMENTAL-
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