Synthesis, Characterization and Electrochemical Detection of Glucose and H2O2, Molecular Docking and Biological Inspection of Transition Metal Complexes of Novel Ligand 2-[(5-methyl-1,3-benzoxazol-2-yl)sulfanyl]acetohydrazide

Abstract

A renowned pharmacophore and structure of great relevance to various fields, benzoxazole is a prominent member of the heterocyclic family. Aside from that, metal complexes can enhance the drug action and efficacy of the organic therapeutic agent. These insights led us to conduct research, including synthesizing and characterizing benzoxazole-derived ligand and metal complexes, assessing their pharmacological properties, and the potential use of the metal complex as a biosensor for sensing glucose and H2O2. The novel ligand MBA and its transition metal complexes are synthesized and characterized for their geometrical composition by varied physical and spectroscopic procedures. Antimicrobial potency was measured by the well diffusion method and antioxidant levels by the DPPH technique. A molecular docking study and MTTtest were carried out to assess anticancer activity for MCF-7 and Hela cell lines. The study results show that MBA bear bidentate coordination and octahedral geometry are ideal for the coordination of metals. The Co(II)MBA/GCE sensor demonstrated astounding electrochemical activity for glucose, and H2O2 and Ni(II) and Cu(II) compounds had impressive antimicrobial and cytotoxic potency, whereas Co(II) and Ni(II) complex were stronger antioxidant agents.