{"title":"Pyrazole as an anti-microbial scaffold: A comprehensive review","authors":"P. Kaur, V. Arora","doi":"10.2174/1570193x20666221031100542","DOIUrl":null,"url":null,"abstract":"\n\nSerious and lethal infectious diseases are caused by pathogenic microorganisms. Numerous anti-microbial agents have been developed during last few decades for treating these infectious diseases, but these are still expanding worldwide over. Moreover, microorganisms are developing resistance against commercially available medicines. So, antimicrobial resistance is expanding as the most serious health threat particularly in developing countries due to easier availability of anti-microbial drugs. So, scarcity of effective antibiotics is suggesting the pressing demand of new anti-microbial agents. Modern drug discovery regarded heterocyclic compounds as its heart due to their striking structural characteristics. Pyrazole is considered as significant heterocyclic nucleus in modern drug development. This review brings a considerable summary regarding derivatives of pyrazole developed over last decade for their anti-microbial action along with docking studies carrying an expectation that it will be beneficial for medicinal chemists working in anti-microbial drug development.\n","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mini-reviews in Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/1570193x20666221031100542","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Serious and lethal infectious diseases are caused by pathogenic microorganisms. Numerous anti-microbial agents have been developed during last few decades for treating these infectious diseases, but these are still expanding worldwide over. Moreover, microorganisms are developing resistance against commercially available medicines. So, antimicrobial resistance is expanding as the most serious health threat particularly in developing countries due to easier availability of anti-microbial drugs. So, scarcity of effective antibiotics is suggesting the pressing demand of new anti-microbial agents. Modern drug discovery regarded heterocyclic compounds as its heart due to their striking structural characteristics. Pyrazole is considered as significant heterocyclic nucleus in modern drug development. This review brings a considerable summary regarding derivatives of pyrazole developed over last decade for their anti-microbial action along with docking studies carrying an expectation that it will be beneficial for medicinal chemists working in anti-microbial drug development.
期刊介绍：
Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges.
The journal encourages submission of reviews on emerging fields of organic chemistry including:
Bioorganic Chemistry
Carbohydrate Chemistry
Chemical Biology
Chemical Process Research
Computational Organic Chemistry
Development of Synthetic Methodologies
Functional Organic Materials
Heterocyclic Chemistry
Macromolecular Chemistry
Natural Products Isolation And Synthesis
New Synthetic Methodology
Organic Reactions
Organocatalysis
Organometallic Chemistry
Theoretical Organic Chemistry
Polymer Chemistry
Stereochemistry
Structural Investigations
Supramolecular Chemistry
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