Inorganic Nanocarriers: Surface Functionalization, Delivery Utility for Natural Therapeutics - A Review

IF 0.5 Q4 ENGINEERING, BIOMEDICAL Journal of Biomimetics, Biomaterials and Biomedical Engineering Pub Date : 2022-08-19 DOI:10.4028/p-96l963

Clarence Rubaka, J. Gathirwa, H. Malebo, H. Swai, A. Hilonga

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Abstract

Inorganic nanocarriers for a decade have increased interest in nanotechnology research platform as versatile drug delivery materials. The utility of the inorganic nanocarriers for delivery of therapeutic agents is attributed to their unique properties such as magnetic, photocatalytic nature and the ability to exhibit surface functionalization. Herein, we review the surface functionalization and delivery utility for natural therapeutics exhibited by inorganic nanocarriers mostly focusing on their magnetic, photocatalytic and the plasmonic properties. The review also highlights the influence of electronic property of inorganic surface on functionalization of ligand based natural therapeutic agents. Improvement of stability and therapeutic potential by formation of nanocomposites are detailed. Furthermore, we suggest improvement strategies for stability and toxicity reduction of inorganic nanoparticles that would potentially make them useful for clinical application as therapeutic delivery tools for treatment of various diseases.

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无机纳米载体:表面功能化，自然疗法的递送效用综述

无机纳米载体作为多用途的给药材料，在纳米技术研究平台上引起了越来越多的兴趣。无机纳米载体用于递送治疗剂的用途归因于其独特的性质，如磁性、光催化性质和表现出表面功能化的能力。在此，我们回顾了无机纳米载体在自然疗法中的表面功能化和递送应用，主要集中在它们的磁性、光催化和等离子体性质上。综述了无机表面电子性质对配体类天然治疗剂功能化的影响。详细介绍了纳米复合材料的稳定性和治疗潜力。此外，我们建议改进无机纳米颗粒的稳定性和降低毒性的策略，这可能使它们作为治疗各种疾病的治疗递送工具在临床应用中有用。

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来源期刊

Journal of Biomimetics, Biomaterials and Biomedical Engineering ENGINEERING, BIOMEDICAL-

CiteScore

1.40

自引率

14.30%

发文量