A Preliminary Study On The Anticancer Properties Of Oxytocin: A Neuroendocrine Regimen With Oxytocin, Antitumor Pineal Indoles, And Cannabidiol In Untreatable Advanced Cancer Patients Progressing On Pineal Indoles And Cannabidiol Alone

Abstract

The recent discovery of several endogenous and exogenous anticancer non-toxic molecules has allowed the possibility to administer potential anticancer curative regimens also in patients, who would be generally considered as eligible for the only palliative therapy. Within the anticancer molecules of the human body, it has been shown that the pineal indole hormones and the endocannabinoid agents may play an anticancer activity against most tumor histotypes through several mechanisms, including cytotoxic, anti-angiogenic and immunostimulatory effect on the anticancer immunity, and to prolong the survival time in advanced cancer patients eligible for the only supportive care. In fact, cancer progression has appeared to be associated with a progressive decline in the functionless of the pineal gland and endocannabinoid system. The endocannabinoid brain activity may be enhanced by the non-psychoactive principle A Preliminary Study on the Anticancer Properties of Oxytocin: A Neuroendocrine Regimen with Oxytocin, Antitumor Pineal Indoles, and Cannabidiol in Untreatable Advanced Cancer Patients Progressing on Pineal Indoles and Cannabidiol Alone. Oncogen 2(4): 18. system [9] and probably to a dimished OXY secretion [13]. Then, the progressive correction of these major cancer-related neuroendocrine deficiencies through an exogenous administration could improve the control of cancer growth. In fact, some preliminary clinical studies have already demonstrated the possibility to enhance the survival time in a considerable number of advanced cancer patients eligible for the only palliative therapy, and also to achieve some tumor regressions even though in a very low percentage of untreatable disseminated cancer patients, through the administration of high-dose pineal indole hormones MLT and 5-MTT [17]. Further studies have shown the possibility to achieve a greater increase in the survival time of untreatable (5-MTT) were given orally at 100 mg/day in the dark period, and at 10 mg/day in the light period, respectively. CBD was also given orally at 10 mg twice/day. Finally, OXY was given orally at 2 mg twice/day in a gastroprotected form. A stable disease (SD) was achieved in 8/14 (57%) patients (gynecologic tumors: 5; TNBC: 2; GBM: 1), whereas 6 patients had a progressive disease (PD). The percentage of 1-year survival obtained in patients with SD was significantly higher than that found in patients with PD. Moreover, a clear improvement in mood, social relationships and pleasure perception was observed in 9/14 (64%) patients under OXY administration. These preliminary results would furtherly confirm the possibility to obtain a control of the neoplastic growth also in advanced cancer patients eligible for the only supportive care alone by simply correcting the main cancer- progression-related endogenous neuroendocrine deficiencies, including pineal system and OXY secretion.