Aruna Talatam, P. K. Reddy, N. Motohashi, Anuradha Vanam, Rao Gollapudi
{"title":"Targeting Overexpressed Cyclin Dependent Kinase 1 (CDK1) in Human Cancers: Kamalachalcone A Emerged as Potential Inhibitor of CDK1 Kinase Through in Silico Docking Study","authors":"Aruna Talatam, P. K. Reddy, N. Motohashi, Anuradha Vanam, Rao Gollapudi","doi":"10.35702/onc.10025","DOIUrl":"https://doi.org/10.35702/onc.10025","url":null,"abstract":"","PeriodicalId":92827,"journal":{"name":"Oncogen","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43370214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mohammadi, J. Mehrzad, Nourouz Delirezh, A. Abdollahi
{"title":"Chronic Inflammation and Its Role in Colorectal Cancer Development","authors":"M. Mohammadi, J. Mehrzad, Nourouz Delirezh, A. Abdollahi","doi":"10.35702/onc.10024","DOIUrl":"https://doi.org/10.35702/onc.10024","url":null,"abstract":"","PeriodicalId":92827,"journal":{"name":"Oncogen","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42706323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does a Healthy and Regular Diet Prevent Cancer? Amazing Medical Benefits of Red Beet (Beta Vulgaris) as an Antioxidant","authors":"H. Cingilli","doi":"10.35702/onc.10023","DOIUrl":"https://doi.org/10.35702/onc.10023","url":null,"abstract":"","PeriodicalId":92827,"journal":{"name":"Oncogen","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48508068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prostate cancer, like other complex biomedical conditions, must be understood from multiple perspectives. This article presents a formal analytic model to serve as a conceptual map for exploring 4 distinctly different domains of prostate cancer. A navigational metaphor is used to reflect the challenges one encounters in crossing over from one domain to the others, without explicit guidelines to aid in this endeavor. Such a model levels the playing field shared by patients, care providers, clinical researchers, and advocates so that informed decisions can be made regarding treatment. It also helps all sub-groups within the prostate cancer community to achieve a deeper understanding of this potentially lethal disease and communicate more effectively with each other.
{"title":"Navigating Prostate Cancer: A Map Of The Territory And Guidelines For Leveling The Playing Field Shared By Patients, Care Providers, Clinical Researchers, And Advocates","authors":"A. Pfadt, Joel Nowak","doi":"10.35702/onc.10019","DOIUrl":"https://doi.org/10.35702/onc.10019","url":null,"abstract":"Prostate cancer, like other complex biomedical conditions, must be understood from multiple perspectives. This article presents a formal analytic model to serve as a conceptual map for exploring 4 distinctly different domains of prostate cancer. A navigational metaphor is used to reflect the challenges one encounters in crossing over from one domain to the others, without explicit guidelines to aid in this endeavor. Such a model levels the playing field shared by patients, care providers, clinical researchers, and advocates so that informed decisions can be made regarding treatment. It also helps all sub-groups within the prostate cancer community to achieve a deeper understanding of this potentially lethal disease and communicate more effectively with each other.","PeriodicalId":92827,"journal":{"name":"Oncogen","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44803975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Lissoni, G. Porro, F. Rovelli, G. Messina, Rosa Cusmai, Alberto Caddeo, R. Trampetti, E. Porta, A. Monzon, M. Roselli, G. Di Fede
The recent discovery of several endogenous and exogenous anticancer non-toxic molecules has allowed the possibility to administer potential anticancer curative regimens also in patients, who would be generally considered as eligible for the only palliative therapy. Within the anticancer molecules of the human body, it has been shown that the pineal indole hormones and the endocannabinoid agents may play an anticancer activity against most tumor histotypes through several mechanisms, including cytotoxic, anti-angiogenic and immunostimulatory effect on the anticancer immunity, and to prolong the survival time in advanced cancer patients eligible for the only supportive care. In fact, cancer progression has appeared to be associated with a progressive decline in the functionless of the pineal gland and endocannabinoid system. The endocannabinoid brain activity may be enhanced by the non-psychoactive principle A Preliminary Study on the Anticancer Properties of Oxytocin: A Neuroendocrine Regimen with Oxytocin, Antitumor Pineal Indoles, and Cannabidiol in Untreatable Advanced Cancer Patients Progressing on Pineal Indoles and Cannabidiol Alone. Oncogen 2(4): 18. system [9] and probably to a dimished OXY secretion [13]. Then, the progressive correction of these major cancer-related neuroendocrine deficiencies through an exogenous administration could improve the control of cancer growth. In fact, some preliminary clinical studies have already demonstrated the possibility to enhance the survival time in a considerable number of advanced cancer patients eligible for the only palliative therapy, and also to achieve some tumor regressions even though in a very low percentage of untreatable disseminated cancer patients, through the administration of high-dose pineal indole hormones MLT and 5-MTT [17]. Further studies have shown the possibility to achieve a greater increase in the survival time of untreatable (5-MTT) were given orally at 100 mg/day in the dark period, and at 10 mg/day in the light period, respectively. CBD was also given orally at 10 mg twice/day. Finally, OXY was given orally at 2 mg twice/day in a gastroprotected form. A stable disease (SD) was achieved in 8/14 (57%) patients (gynecologic tumors: 5; TNBC: 2; GBM: 1), whereas 6 patients had a progressive disease (PD). The percentage of 1-year survival obtained in patients with SD was significantly higher than that found in patients with PD. Moreover, a clear improvement in mood, social relationships and pleasure perception was observed in 9/14 (64%) patients under OXY administration. These preliminary results would furtherly confirm the possibility to obtain a control of the neoplastic growth also in advanced cancer patients eligible for the only supportive care alone by simply correcting the main cancer- progression-related endogenous neuroendocrine deficiencies, including pineal system and OXY secretion.
{"title":"A Preliminary Study On The Anticancer Properties Of Oxytocin: A Neuroendocrine Regimen With Oxytocin, Antitumor Pineal Indoles, And Cannabidiol In Untreatable Advanced Cancer Patients Progressing On Pineal Indoles And Cannabidiol Alone","authors":"P. Lissoni, G. Porro, F. Rovelli, G. Messina, Rosa Cusmai, Alberto Caddeo, R. Trampetti, E. Porta, A. Monzon, M. Roselli, G. Di Fede","doi":"10.35702/onc.10018","DOIUrl":"https://doi.org/10.35702/onc.10018","url":null,"abstract":"The recent discovery of several endogenous and exogenous anticancer non-toxic molecules has allowed the possibility to administer potential anticancer curative regimens also in patients, who would be generally considered as eligible for the only palliative therapy. Within the anticancer molecules of the human body, it has been shown that the pineal indole hormones and the endocannabinoid agents may play an anticancer activity against most tumor histotypes through several mechanisms, including cytotoxic, anti-angiogenic and immunostimulatory effect on the anticancer immunity, and to prolong the survival time in advanced cancer patients eligible for the only supportive care. In fact, cancer progression has appeared to be associated with a progressive decline in the functionless of the pineal gland and endocannabinoid system. The endocannabinoid brain activity may be enhanced by the non-psychoactive principle A Preliminary Study on the Anticancer Properties of Oxytocin: A Neuroendocrine Regimen with Oxytocin, Antitumor Pineal Indoles, and Cannabidiol in Untreatable Advanced Cancer Patients Progressing on Pineal Indoles and Cannabidiol Alone. Oncogen 2(4): 18. system [9] and probably to a dimished OXY secretion [13]. Then, the progressive correction of these major cancer-related neuroendocrine deficiencies through an exogenous administration could improve the control of cancer growth. In fact, some preliminary clinical studies have already demonstrated the possibility to enhance the survival time in a considerable number of advanced cancer patients eligible for the only palliative therapy, and also to achieve some tumor regressions even though in a very low percentage of untreatable disseminated cancer patients, through the administration of high-dose pineal indole hormones MLT and 5-MTT [17]. Further studies have shown the possibility to achieve a greater increase in the survival time of untreatable (5-MTT) were given orally at 100 mg/day in the dark period, and at 10 mg/day in the light period, respectively. CBD was also given orally at 10 mg twice/day. Finally, OXY was given orally at 2 mg twice/day in a gastroprotected form. A stable disease (SD) was achieved in 8/14 (57%) patients (gynecologic tumors: 5; TNBC: 2; GBM: 1), whereas 6 patients had a progressive disease (PD). The percentage of 1-year survival obtained in patients with SD was significantly higher than that found in patients with PD. Moreover, a clear improvement in mood, social relationships and pleasure perception was observed in 9/14 (64%) patients under OXY administration. These preliminary results would furtherly confirm the possibility to obtain a control of the neoplastic growth also in advanced cancer patients eligible for the only supportive care alone by simply correcting the main cancer- progression-related endogenous neuroendocrine deficiencies, including pineal system and OXY secretion.","PeriodicalId":92827,"journal":{"name":"Oncogen","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48803295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management Interventions And Public Health Policies: Prevention, Control And Palliative Care In Oncology","authors":"Clevson Santos Passos, É. Sady, C. S. Passos","doi":"10.35702/onc.10016","DOIUrl":"https://doi.org/10.35702/onc.10016","url":null,"abstract":"","PeriodicalId":92827,"journal":{"name":"Oncogen","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42244895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick Schouml, ffski, G. Moors, P. Clement, H. Dumez, O. Bechter
Results: MCC is a chemotherapy-sensitive tumour with an objective response rate of 63% to first-line chemotherapy. The combination of cisplatin or carboplatin with etoposide was the most frequently used regimen (n=13) with responses seen in 69% of patients. The median progression-free survival after first-line chemotherapy was 8 months. Eight patients received second line chemotherapy with gemcitabine, taxanes or vinca alkaloids with a response rate of 25%. The median overall survival since start of first line chemotherapy was 13 months. Conclusions: A considerable proportion of patients with MCC fails local treatments and requires systemic therapy. Advanced MCC is a chemotherapy-sensitive disease with high response rates. The poor overall survival achieved with chemotherapy supports the need for novel systemic strategies, such as the routine implementation of immunologic treatment approaches. Immune checkpoint modulation is complementary to chemotherapy, and should be further developed as single agent, in sequence or in combination with other biological or cytotoxic therapy.
{"title":"Palliative Systemic Treatment of Advanced Merkel Cell Carcinoma in the Pre-Immunotherapy Era: A Retrospective, Single-Center Analysis of Patients with An Orphan Neuroendocrine Malignancy","authors":"Patrick Schouml, ffski, G. Moors, P. Clement, H. Dumez, O. Bechter","doi":"10.35702/onc.10014","DOIUrl":"https://doi.org/10.35702/onc.10014","url":null,"abstract":"Results: MCC is a chemotherapy-sensitive tumour with an objective response rate of 63% to first-line chemotherapy. The combination of cisplatin or carboplatin with etoposide was the most frequently used regimen (n=13) with responses seen in 69% of patients. The median progression-free survival after first-line chemotherapy was 8 months. Eight patients received second line chemotherapy with gemcitabine, taxanes or vinca alkaloids with a response rate of 25%. The median overall survival since start of first line chemotherapy was 13 months. Conclusions: A considerable proportion of patients with MCC fails local treatments and requires systemic therapy. Advanced MCC is a chemotherapy-sensitive disease with high response rates. The poor overall survival achieved with chemotherapy supports the need for novel systemic strategies, such as the routine implementation of immunologic treatment approaches. Immune checkpoint modulation is complementary to chemotherapy, and should be further developed as single agent, in sequence or in combination with other biological or cytotoxic therapy.","PeriodicalId":92827,"journal":{"name":"Oncogen","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48673736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Sabit, Doha Alaa, Nourhan Jamal, Sodfa Tarek, Magda Fouda, Bassant Maher, A. Prince, S. Abdel-Ghany, E. Çevik, Huseyin Tombuoglu, Osama A. M. Said, A. Sabry, A. Al-Muhanna, M. El-Zawahri
{"title":"CRISPR/Cas9-based Editing of CDK4, p107, and TGFβ1 in Human Breast and Lung Cancer Cells","authors":"H. Sabit, Doha Alaa, Nourhan Jamal, Sodfa Tarek, Magda Fouda, Bassant Maher, A. Prince, S. Abdel-Ghany, E. Çevik, Huseyin Tombuoglu, Osama A. M. Said, A. Sabry, A. Al-Muhanna, M. El-Zawahri","doi":"10.35702/ONC.10015","DOIUrl":"https://doi.org/10.35702/ONC.10015","url":null,"abstract":"","PeriodicalId":92827,"journal":{"name":"Oncogen","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48035281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The acid-mediated tumor invasion hypothesis proposes that altered glucose metabolism exhibited by the vast majority of tumors leads to increased acid (H+ ion) production which subsequently facilitates tumor invasion [1-3]. The reaction-diffusion model [2] that captures the key elements of the hypothesis shows how the densities of normal cells, tumor cells, and excess H+ ions change with time due to both chemical reactions between these three populations and density-dependent diffusion by which they spread out in three-dimensional space. Moreover, it proposes that each cell has an optimal pH for survival; that is, if the local pH deviates from the optimal value in either an acidic or alkaline direction, the cells begin to die, and that the death rate saturates at some maximum value when the microenvironment is extremely acidic or alkaline. We have previously studied in detail how the death-rate functions of the normal and tumor populations depend upon the H+ ion density [4]. Here, we extend previous work by investigating how the equilibrium densities (at which the time rates of change of the cellular densities are equal to zero) reached by the normal and tumor populations in three-dimensional space are affected by the presence of the H+ ions, and we present detailed analytical and computational techniques to analyze the dynamical stability of these equilibrium densities. For a sample set of biological input parameters and within the acid-mediation hypothesis, our model predicts the transformation to a malignant behavior, as indicated by the presence of unstable sets of equilibrium densities.
{"title":"Dynamical Stability Analysis Of Tumor Growth And Invasion: A Reaction- Diffusion Model","authors":"A. Fouad","doi":"10.35702/onc.10020","DOIUrl":"https://doi.org/10.35702/onc.10020","url":null,"abstract":"The acid-mediated tumor invasion hypothesis proposes that altered glucose metabolism exhibited by the vast majority of tumors leads to increased acid (H+ ion) production which subsequently facilitates tumor invasion [1-3]. The reaction-diffusion model [2] that captures the key elements of the hypothesis shows how the densities of normal cells, tumor cells, and excess H+ ions change with time due to both chemical reactions between these three populations and density-dependent diffusion by which they spread out in three-dimensional space. Moreover, it proposes that each cell has an optimal pH for survival; that is, if the local pH deviates from the optimal value in either an acidic or alkaline direction, the cells begin to die, and that the death rate saturates at some maximum value when the microenvironment is extremely acidic or alkaline. We have previously studied in detail how the death-rate functions of the normal and tumor populations depend upon the H+ ion density [4]. Here, we extend previous work by investigating how the equilibrium densities (at which the time rates of change of the cellular densities are equal to zero) reached by the normal and tumor populations in three-dimensional space are affected by the presence of the H+ ions, and we present detailed analytical and computational techniques to analyze the dynamical stability of these equilibrium densities. For a sample set of biological input parameters and within the acid-mediation hypothesis, our model predicts the transformation to a malignant behavior, as indicated by the presence of unstable sets of equilibrium densities.","PeriodicalId":92827,"journal":{"name":"Oncogen","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48207427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Sharma, Vaishna Prabhakaran, Akash Desai, J. Bajpai, R. Verma, P. Swain
Studies on post-translational modifications (PTMs) have grabbed attention of the scientific community worldwide, its role in pathogenesis of cancer and prognostic biomarkers associated with cancers. However, unraveling the specific role of PTMs in carcinogenesis or in predictive biomarkers requires holistic understanding of the cancer types and associated mechanisms. Manifestation of cancer is complex and involves multiple steps including modifications at the levels of genes, associated proteins and signaling pathways. Biomarkers, as a prognostic marker, are critical in deciding efficacy of the clinical outcomes in malignancies. Growing evidence suggests that several biomarkers that are post-translationally modified play important role in human cancers. In the current review, few of such biomarkers and targets that are post-translationally modified and are associated with carcinogenesis are collated and analyzed to provide a bird’s eye view of their role in cancer types. Such analysis will help in understanding the pathogenesis and the precise role of biomarkers in designing better therapeutic interventions for different cancer types.
{"title":"Post-translational Modifications (PTMs), from a Cancer Perspective: An Overview","authors":"B. Sharma, Vaishna Prabhakaran, Akash Desai, J. Bajpai, R. Verma, P. Swain","doi":"10.35702/ONC.10012","DOIUrl":"https://doi.org/10.35702/ONC.10012","url":null,"abstract":"Studies on post-translational modifications (PTMs) have grabbed attention of the scientific community worldwide, its role in pathogenesis of cancer and prognostic biomarkers associated with cancers. However, unraveling the specific role of PTMs in carcinogenesis or in predictive biomarkers requires holistic understanding of the cancer types and associated mechanisms. Manifestation of cancer is complex and involves multiple steps including modifications at the levels of genes, associated proteins and signaling pathways. Biomarkers, as a prognostic marker, are critical in deciding efficacy of the clinical outcomes in malignancies. Growing evidence suggests that several biomarkers that are post-translationally modified play important role in human cancers. In the current review, few of such biomarkers and targets that are post-translationally modified and are associated with carcinogenesis are collated and analyzed to provide a bird’s eye view of their role in cancer types. Such analysis will help in understanding the pathogenesis and the precise role of biomarkers in designing better therapeutic interventions for different cancer types.","PeriodicalId":92827,"journal":{"name":"Oncogen","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43433746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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