A Review on Synthesis, Characterization, and Pharmacological Properties of Some Sydnone Derivatives

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC Mini-reviews in Organic Chemistry Pub Date : 2023-08-31 DOI:10.2174/1570193x21666230831153810
T. Khan, Ritu Yadav, A. K. Kesharwani, Karuna Chourasia
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Abstract

The mesoionic compounds have great importance due to their dipolar nature. They are versatile synthons in synthetic chemistry and possess various chemotherapeutic activities. The most important moiety found in mesoionic compounds is the sydnone ring system. Sydnone derivatives have stimulated much interest among synthetic researchers as a result of their unique dipolar, mesoionic character. This ring system is also associated with a wide variety of biological activities. Sydnone derivatives have various applications in synthetic and medicinal chemistry. Sydnones are very useful precursors for selective heterocycles (pyrazoles, imidazoles, oxadiazoles, oxazoles, thiazoles, and tetrazoles), which has also served to initiate research into their functionalization and cycloaddition chemistry, paving the way for stimulated extensive research on the use of sydnones in chemical and industrial applications. So, this review article offers a wide scope of synthesis and applications of sydnone derivatives.
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一些syd酮衍生物的合成、表征及药理性质的研究进展
介电离子化合物由于其偶极性质而具有重要意义。它们是合成化学中的多功能合成子,具有多种化学治疗活性。在介电离子化合物中发现的最重要的部分是sydnone环系统。Sydnone衍生物由于其独特的偶极、介电性质而引起了合成研究人员的极大兴趣。这个环状系统还与各种各样的生物活动有关。Sydnone衍生物在合成化学和药物化学中有各种应用。Sydnone是选择性杂环(吡唑、咪唑、恶二唑、恶唑、噻唑和四唑)的非常有用的前体,这也有助于启动对其功能化和环加成化学的研究,为促进Sydnone在化学和工业应用中的广泛研究铺平了道路。因此,本文对sydnone衍生物的合成和应用进行了综述。
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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