Hypereosinophilia with IgG4 Associated Cholangiopathy

R. Slim, Antoine Assaf, Maria Karam, V. Smayra, L. Menassa
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Abstract

IgG4-related sclerosing cholangitis (IgG4-SC) belongs to the spectrum of IgG4-related disease which encompasses many medical conditions. We report a case of a 59-year-old man who presented with clinical and radiologic features of primary sclerosing cholangitis but where hypereosinophilia along with an extremely high blood level of IgG4, liver infiltration with IgG4-positive plasma cell and a spectacular response to corticoids treatment, confirmed the diagnosis of IgG4-SC.
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嗜酸性粒细胞增多伴IgG4相关胆管病变
IgG4相关硬化性胆管炎(IgG4SC)属于IgG4相关疾病的谱系,包括许多疾病。我们报告了一例59岁的男性病例,他表现出原发性硬化性胆管炎的临床和放射学特征,但嗜酸性粒细胞增多伴极高的IgG4血液水平、IgG4阳性浆细胞的肝脏浸润和对皮质类固醇治疗的显著反应,证实了IgG4-SC的诊断。
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