Current status of clinical application of immunotherapy in the treatment of glioma: A narrative review

Glioma Pub Date : 2023-01-01 DOI:10.4103/glioma.glioma_2_23
Qiuzi Chen, Peng Ren, Guo-Hao Huang, Zuoxin Zhang, J. Hugnot, S. Lv
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Abstract

Glioma is a common type of brain tumor. Current treatment for glioma includes surgical resection, radiotherapy, chemotherapy, and tumor-treating fields. The application of immunotherapy to treat glioma is still far from satisfactory in the clinic. Here, we review the mechanisms of immunotherapy for glioma (including immune checkpoint inhibitor, chimeric antigen receptor-T-cell, tumor vaccine, and oncolytic virus) and the results of completed clinical trials, and will discuss the current status of immunotherapy and possible future directions.
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免疫疗法治疗胶质瘤的临床应用现状综述
胶质瘤是一种常见的脑肿瘤。目前对神经胶质瘤的治疗包括手术切除、放疗、化疗和肿瘤治疗领域。免疫疗法在神经胶质瘤治疗中的应用在临床上还远远不能令人满意。在此,我们回顾了神经胶质瘤免疫治疗的机制(包括免疫检查点抑制剂、嵌合抗原受体T细胞、肿瘤疫苗和溶瘤病毒)和已完成的临床试验结果,并将讨论免疫治疗的现状和可能的未来方向。
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来源期刊
自引率
0.00%
发文量
12
审稿时长
42 weeks
期刊最新文献
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