Qiuzi Chen, Peng Ren, Guo-Hao Huang, Zuoxin Zhang, J. Hugnot, S. Lv
{"title":"Current status of clinical application of immunotherapy in the treatment of glioma: A narrative review","authors":"Qiuzi Chen, Peng Ren, Guo-Hao Huang, Zuoxin Zhang, J. Hugnot, S. Lv","doi":"10.4103/glioma.glioma_2_23","DOIUrl":null,"url":null,"abstract":"Glioma is a common type of brain tumor. Current treatment for glioma includes surgical resection, radiotherapy, chemotherapy, and tumor-treating fields. The application of immunotherapy to treat glioma is still far from satisfactory in the clinic. Here, we review the mechanisms of immunotherapy for glioma (including immune checkpoint inhibitor, chimeric antigen receptor-T-cell, tumor vaccine, and oncolytic virus) and the results of completed clinical trials, and will discuss the current status of immunotherapy and possible future directions.","PeriodicalId":12731,"journal":{"name":"Glioma","volume":"6 1","pages":"3 - 8"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Glioma","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/glioma.glioma_2_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Glioma is a common type of brain tumor. Current treatment for glioma includes surgical resection, radiotherapy, chemotherapy, and tumor-treating fields. The application of immunotherapy to treat glioma is still far from satisfactory in the clinic. Here, we review the mechanisms of immunotherapy for glioma (including immune checkpoint inhibitor, chimeric antigen receptor-T-cell, tumor vaccine, and oncolytic virus) and the results of completed clinical trials, and will discuss the current status of immunotherapy and possible future directions.