Clinical-haemostasis assessment of anaesthesia regimens in dogs with visceral and somatic types of pain response

Abstract

The article investigates the influence of visceral (surgical treatment of abdominal pathologies) and somatic pain syndrome (osteosynthesis) on dogs’ clinical parameters and haemostasis. It was found, that the best variant for abdominal operations in dogs is acepromazine-ketamine-propofol anaesthesia and for osteosynthesis – acepromazine-butorphanol-ketamine. The use of neuroleptics (acepromazine, xylazine) with general anaesthetics (ketamine, propofol, sodium thiopental) in abdominal operations ensured rapid entry into anaesthesia (< 2 min) and duration 19–23 min. The use of acepromazine-ketamine-propofol provided well-managed anaesthesia during 11.1 ± 0.5 min, rapid recovery (17.3 ± 2.4 min), without significant changes in heart rate (HR), respiratory rate (RR), blood pressure (BP), haemoglobin saturation (SpO2). Unbalanced anaesthesia and insufficient analgesia under xylazine-ketamine caused a sharp decrease in HR, BP, RR with their increase due to visceral pain, led to hypoxia (SpO2 < 92%). During the osteosynthesis, acepromazine-butorphanol-propofol-ketamine anaesthesia provided complete analgesia with twice the rapid recovery of dogs without significant changes in HR, RR, BP, SpO2 during surgery. Acepromazine-ketamine-thiopental anaesthesia accompanied by pronounced analgesia with a decrease in HR and BP. Xylazine-ketamine-thiopental anaesthesia, under apparent analgesia, led to hypotension (decreased HR, BP) and hypoxia (decreased RR, SpO2). The data obtained will optimize the selection of drugs' combinations for dogs' anaesthesia, taking into account the type of pain response.