{"title":"Research progress in relationship between level of thrombopoietin and clonal hematopoiesis","authors":"P. Dong","doi":"10.3760/CMA.J.ISSN.1673-419X.2019.03.016","DOIUrl":null,"url":null,"abstract":"Recent genomic studies have revealed the existence of many somatic gene mutations associated with hematologic malignancies. These somatic mutations drive the expansion from a single cell to a detectable hematopoietic clone. Clonal hematopoiesis (CH) is age-associated and related to increased risk of hematologic malignancy. Thrombopoietin (TPO) stimulates megakaryocytogenesis, platelet activation and hematopoietic stem cell(HSC) maintenance after combining with c-MPL on cell surface. Increasing researches have revealed the relationship between the level of TPO and CH. This article reviews the reasearch progress in the relationship between level of TPO and CH, in order to provide evidences for clinical prevention, diagnosis and treatment of hematologic malignancies. \n \n \nKey words: \nThrombopoietin; Hematopoiesis; Mutation; Hematologic neoplasms; Clonal evolution; MPL protein, human","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"42 1","pages":"264-267"},"PeriodicalIF":0.0000,"publicationDate":"2019-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2019.03.016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Recent genomic studies have revealed the existence of many somatic gene mutations associated with hematologic malignancies. These somatic mutations drive the expansion from a single cell to a detectable hematopoietic clone. Clonal hematopoiesis (CH) is age-associated and related to increased risk of hematologic malignancy. Thrombopoietin (TPO) stimulates megakaryocytogenesis, platelet activation and hematopoietic stem cell(HSC) maintenance after combining with c-MPL on cell surface. Increasing researches have revealed the relationship between the level of TPO and CH. This article reviews the reasearch progress in the relationship between level of TPO and CH, in order to provide evidences for clinical prevention, diagnosis and treatment of hematologic malignancies.
Key words:
Thrombopoietin; Hematopoiesis; Mutation; Hematologic neoplasms; Clonal evolution; MPL protein, human
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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