The role of collagens in glioma: A narrative review

Glioma Pub Date : 2022-04-01 DOI:10.4103/glioma.glioma_11_22
Yi Wang, Toshiya Ichinose, M. Nakada
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Abstract

Glioma is the most common brain tumor in the central nervous system and characterized by diffuse invasion into adjacent brain tissue. The extracellular matrix (ECM) is an essential component of the tumor microenvironment and it contributes to tumor progression through close interactions with glioma cells. Accumulated evidence has indicated that collagen levels, which are the most critical components of the ECM, are elevated in gliomas and collagen contributes to glioma progression. In this review, we provide a comprehensive summary of the roles of various collagens in glioma. A better understanding of the interactions of various collagens with glioma cells may provide new therapeutic strategies for gliomas.
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胶原在神经胶质瘤中的作用:综述
胶质瘤是中枢神经系统中最常见的脑肿瘤,其特征是弥漫性侵犯邻近的脑组织。细胞外基质(ECM)是肿瘤微环境的重要组成部分,它通过与神经胶质瘤细胞的密切相互作用促进肿瘤进展。积累的证据表明,作为ECM最关键成分的胶原蛋白水平在胶质瘤中升高,胶原蛋白有助于胶质瘤的进展。在这篇综述中,我们对各种胶原蛋白在神经胶质瘤中的作用进行了全面的总结。更好地了解各种胶原与神经胶质瘤细胞的相互作用可能为神经胶质瘤的治疗提供新的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
自引率
0.00%
发文量
12
审稿时长
42 weeks
期刊最新文献
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