Advances in the Management of Pemphigus Vulgaris: A Review Article

Abstract

Pemphigus Vulgaris (PV) is a debilitating autoimmune disease with a genetic predilection. In most cases, PV affects the oral mucosa, but can also occur in conjunction with skin lesions affecting different areas of the body. Lesions affecting the oral mucosa are characterized by the presence of erosions whereas, skin lesions appear mainly as flaccid bulla in their early stages or as erosions later in the disease course. Pemphigus Vulgarisis characterized by the formation of highly fragile bulla that frequently ruptures, forming denuded, painful, easily bleeding erosions that often become crusted. Proper diagnosis is considered a significant component of early and efficient management, resulting in less morbidity. The use of corticosteroids in conjunction with immunosuppressant drugs such as azathioprine and mycophenolatein the management of acute attacks has been applied throughout the years (1).