Pub Date : 2024-03-06DOI: 10.34257/gjmrjvol24is1pg5
Dr. Kirti Saharan, Dr. Shivaprasad S., Dr. Ashok L.
Aims:1) To measure the height and width of the mandibular ramus and height of the body of the mandible on digital orthopantomograms. 2) To compare the measurements on the mandibular ramus & body of the mandible and use them in gender determination. Setting and Design: Retrospective study on 120 retrieved digital ortho pantomograms of individuals of Indian origin. Materials and Methods: A study was conducted on 120 retrieved digital orthopantomograms which were categorized into three age groups of age between 21-50 years. 40 digital orthopantomograms were selected under each age group which included 20 male and 20 female radiographs. The Digital OPG images that were obtained using the PLANMECA PROLINE XC machine were measured using PLANMECA ROMEXIS 2.3.1.R software.
{"title":"Gender Determination by Measuring the Mandibular Ramus and Body of the Mandible: A Retrospective Radiographic Study","authors":"Dr. Kirti Saharan, Dr. Shivaprasad S., Dr. Ashok L.","doi":"10.34257/gjmrjvol24is1pg5","DOIUrl":"https://doi.org/10.34257/gjmrjvol24is1pg5","url":null,"abstract":"Aims:1) To measure the height and width of the mandibular ramus and height of the body of the mandible on digital orthopantomograms. 2) To compare the measurements on the mandibular ramus & body of the mandible and use them in gender determination.\u0000Setting and Design: Retrospective study on 120 retrieved digital ortho pantomograms of individuals of Indian origin.\u0000Materials and Methods: A study was conducted on 120 retrieved digital orthopantomograms which were categorized into three age groups of age between 21-50 years. 40 digital orthopantomograms were selected under each age group which included 20 male and 20 female radiographs. The Digital OPG images that were obtained using the PLANMECA PROLINE XC machine were measured using PLANMECA ROMEXIS 2.3.1.R software.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"69 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140261281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-24DOI: 10.34257/gjmrcvol24is1pg1
Caroline Mitiká Watanabe, Nathália Almeida Souza Tancler, Aline Márcia Marques Braz, Shelly Favorito de Carvalho, Giovanni Faria Silva, Maria Inês de Moura Campos Pardini, Maria Aparecida Custódio Domingues, Guilherme Targino Valente, Paulo Eduardo de Abreu Machado, Rejane Maria Tommasini Grotto, Marjorie de Assis Golim
This study aimed to determine whether the hepatitis C virus (HCV) infects human megakaryocytes and platelets and to measure the expression of receptors involved in virus-cell interaction. Platelets from healthy donors were infected with HCV in vitro and analyzed for viral expression and the receptors claudin-1 and cluster of differentiation 81 (CD81). HCV was detected on the surface and cytoplasm of both cells; cytoplasmic expression was higher compared to the surface. Platelets presented a claudin-1+/CD81-phenotype, and megakaryocytes showed aclaudin-1+/CD81+ phenotype. We conclude that megakaryocytes and platelets are susceptible to HCV infection, regardless of CD81 expression, and megakaryocytes may serve as possible sites of viral replication.
{"title":"Hepatitis C Virus Infected Human Megakaryocytes and Platelets: Intra-and Extracellular Evaluation","authors":"Caroline Mitiká Watanabe, Nathália Almeida Souza Tancler, Aline Márcia Marques Braz, Shelly Favorito de Carvalho, Giovanni Faria Silva, Maria Inês de Moura Campos Pardini, Maria Aparecida Custódio Domingues, Guilherme Targino Valente, Paulo Eduardo de Abreu Machado, Rejane Maria Tommasini Grotto, Marjorie de Assis Golim","doi":"10.34257/gjmrcvol24is1pg1","DOIUrl":"https://doi.org/10.34257/gjmrcvol24is1pg1","url":null,"abstract":"This study aimed to determine whether the hepatitis C virus (HCV) infects human megakaryocytes and platelets and to measure the expression of receptors involved in virus-cell interaction. Platelets from healthy donors were infected with HCV in vitro and analyzed for viral expression and the receptors claudin-1 and cluster of differentiation 81 (CD81). HCV was detected on the surface and cytoplasm of both cells; cytoplasmic expression was higher compared to the surface. Platelets presented a claudin-1+/CD81-phenotype, and megakaryocytes showed aclaudin-1+/CD81+ phenotype. We conclude that megakaryocytes and platelets are susceptible to HCV infection, regardless of CD81 expression, and megakaryocytes may serve as possible sites of viral replication.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"34 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140434201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23DOI: 10.34257/ljmhrvol23is2pg1
Juárez-Palma Lilia, Alejandro Alvarado Delgado, Mario Henry Rodriguez
Insects lack an adaptive immune defense against invading microorganisms, but they possess humoral and cellular response similar to that of vertebrates. The Immune Deficiency (IMD) and Toll are the major signaling pathways to produce humoral antimicrobial peptides AMPs. Pathogen molecular patterns (PAMs) of Gram-negative bacteria activate Pattern recognition receptors (PRR) of the IMD pathway, while PAMS of Gram-positive activate PRR of the Toll pathway. Although the IMD pathways is incomplete in Hemipterans, in Triatoma pallidipennis, there is a preferential participation of the IMD pgrp-lc and toll receptors in the responses to Gramnegative and Gram-positive bacteria, respectively. Still, as in other insects, cross induction was observed. An enhanced protection after a previous exposure to a pathogen, termed priming, functionally homologous to the adaptive immune memory of vertebrates, has been documented in several insect Orders but not in Hemiptera, and the participation of the components of the immune signaling cascades remains poorly explored. We present evidence for immune priming to Micrococcus luteus (Gram-positive) and Escherichia coli (Gramnegative) bacteria in T. pallidipennis. The preferential participation of receptors of the IMD and Toll pathways in the responses to each bacterial challenge was recorded
{"title":"Preferential Induction of Canonical IMD and Toll Innate Immune Receptors by Bacterial\u0000Challenges in Triatoma Pallidipennis Primed with Gram-Negative and Gram-Positive Bacteria, Respectively","authors":"Juárez-Palma Lilia, Alejandro Alvarado Delgado, Mario Henry Rodriguez","doi":"10.34257/ljmhrvol23is2pg1","DOIUrl":"https://doi.org/10.34257/ljmhrvol23is2pg1","url":null,"abstract":"Insects lack an adaptive immune defense against invading microorganisms, but they possess humoral and cellular response similar to that of vertebrates. The Immune Deficiency (IMD) and Toll are the major signaling pathways to produce humoral antimicrobial peptides AMPs. Pathogen molecular patterns (PAMs) of Gram-negative bacteria activate Pattern recognition receptors (PRR) of the IMD pathway, while PAMS of Gram-positive activate PRR of the Toll pathway. Although the IMD pathways is incomplete in Hemipterans, in Triatoma pallidipennis, there is a preferential participation of the IMD pgrp-lc and toll receptors in the responses to Gramnegative and Gram-positive bacteria, respectively. Still, as in other insects, cross induction was observed. An enhanced protection after a previous exposure to a pathogen, termed priming, functionally homologous to the adaptive immune memory of vertebrates, has been documented in several insect Orders but not in Hemiptera, and the participation of the components of the immune signaling cascades remains poorly explored. We present evidence for immune priming to Micrococcus luteus (Gram-positive) and Escherichia coli (Gramnegative) bacteria in T. pallidipennis. The preferential participation of receptors of the IMD and Toll pathways in the responses to each bacterial challenge was recorded","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"25 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140436418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Peptidylprolyl isomerase B (PPIB) has been shown to play an essential role in tumor initiation and progression. However, it lacks systematic analysis and evaluation of the effect of PPIB on pan-cancer. Methods: The expression profile and survival analysis of PPIB in tumor tissues were demonstrated by the TIMER2.0, GEPIA2.0, and UALCAN online tools. The cBioportal, GSCA, TISDB, and TIMER2.0 databases were applied to analyze the correlation between PPIB and genetic variation, immune infiltration, and cancer-associated fibroblasts (CAFs), respectively. The STRING, GEPIA2.0, and TIMER2.0 databases were used to identify the co-expressed genes of PPIB. The DAVID online database was used for GO and KEGG pathway analysis. Results: PPIB was highly expressed in 20 types of tumors. Upregulation of PPIB was associated with a poor prognosis of 6 types of tumors (P<0.05). In most cancers, the frequency of PPIB genetic variation is relatively low, and the common mutation types are missense mutations and splices.
{"title":"PPIB Unveiled: A Comprehensive Pan-Cancer Exploration Unraveling Immunological Signatures and Prognostic Implications","authors":"Ouyang Yan, Qi Dai, Shengming Lai, Haiyan Huang, Yongsheng Huang, Shuwei Ren","doi":"10.34257/gjmrfvol24is1pg1","DOIUrl":"https://doi.org/10.34257/gjmrfvol24is1pg1","url":null,"abstract":"Background: Peptidylprolyl isomerase B (PPIB) has been shown to play an essential role in tumor initiation and progression. However, it lacks systematic analysis and evaluation of the effect of PPIB on pan-cancer.\u0000Methods: The expression profile and survival analysis of PPIB in tumor tissues were demonstrated by the TIMER2.0, GEPIA2.0, and UALCAN online tools. The cBioportal, GSCA, TISDB, and TIMER2.0 databases were applied to analyze the correlation between PPIB and genetic variation, immune infiltration, and cancer-associated fibroblasts (CAFs), respectively. The STRING, GEPIA2.0, and TIMER2.0 databases were used to identify the co-expressed genes of PPIB. The DAVID online database was used for GO and KEGG pathway analysis.\u0000Results: PPIB was highly expressed in 20 types of tumors. Upregulation of PPIB was associated with a poor prognosis of 6 types of tumors (P<0.05). In most cancers, the frequency of PPIB genetic variation is relatively low, and the common mutation types are missense mutations and splices.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"13 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.34257/gjmrfvol24is1pg13
Jéssica de Paula Chalup Junqueira, Lais de Souza Rodrigues, Maria Aparecida de Almeida Souza Rodrigues, Ivana Picone Borges de Aragão
Cardiovascular diseases are the leading cause of death in the world, with smoking, diabetes, high blood pressure, dyslipidemia and a sedentary lifestyle being among the main risk factors. The objective of this study was to evaluate the self knowledge about cardiovascular risk factors among medical students. Methodology: Observational and cross-sectional study on students from the first to the eighth semester of medicine using anonymous questionnaires containing questions about cardiovascular risk factors. Results: A total of 288 students paticipeted. There was a higher percentage of self-declared emotional stress (p<0.001), and high blood pressure (p=0.007), family history of coronary heart disease (CAD) or stroke (0.049) in the female group; The group under 20 years old practiced more physical activity (p=0.023) and reported a balanced diet (p=0.047), the age group between 20 and 29 years old reported a higher percentage of smoking (p=0.001) and alcohol consumption (p=0.048), those older than 30 years old reported a higher knowledge about family history of CAD or stroke.
{"title":"Self-Reported Cardiovascular Risk Factors among Medical Students","authors":"Jéssica de Paula Chalup Junqueira, Lais de Souza Rodrigues, Maria Aparecida de Almeida Souza Rodrigues, Ivana Picone Borges de Aragão","doi":"10.34257/gjmrfvol24is1pg13","DOIUrl":"https://doi.org/10.34257/gjmrfvol24is1pg13","url":null,"abstract":"Cardiovascular diseases are the leading cause of death in the world, with smoking, diabetes, high blood pressure, dyslipidemia and a sedentary lifestyle being among the main risk factors. The objective of this study was to evaluate the self knowledge about cardiovascular risk factors among medical students.\u0000Methodology: Observational and cross-sectional study on students from the first to the eighth semester of medicine using anonymous questionnaires containing questions about cardiovascular risk factors.\u0000Results: A total of 288 students paticipeted. There was a higher percentage of self-declared emotional stress (p<0.001), and high blood pressure (p=0.007), family history of coronary heart disease (CAD) or stroke (0.049) in the female group; The group under 20 years old practiced more physical activity (p=0.023) and reported a balanced diet (p=0.047), the age group between 20 and 29 years old reported a higher percentage of smoking (p=0.001) and alcohol consumption (p=0.048), those older than 30 years old reported a higher knowledge about family history of CAD or stroke.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"16 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140441661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.34257/ljmhrvol24is2pg19
Prof. Arturo Martí Carvajal, MD, MSc. PhD
Background: Citicoline, a medical food prescribed for ischemic stroke, faces scrutiny due to itsb unproven ef icacy and potential harms. This essay, drawing on a recent Cochrane review and focusing solely on all-cause mortality, advocates for a critical reevaluation of its use. Rather than of ering an updated Cochrane review, this analysis provides a reflective perspective through the lens of Evidence-based Medicine and Philosophy of Science. Question Research: Why citicoline (a medical food) should not be prescribed to treat people with acute ischemic stroke: The certainty of the Evidence.? Objective: Demonstrate from evidence-based medicine and philosophy of science perspective that citicoline should not be prescribed for acute ischemic stroke due to lack of ef icacy and harm uncertainties. Search publications: We searched in PubMed and Cochrane Library from 2020 until 30 October 2023. We, furthermore, used engineering machines Bing and Google Scholar to detec additional papers. Additionally, we also reviewed reference lists of the retrieved publications and review articles and searched the websites of the U. S. Food and Drug Administration (FDA) and European Medicines Agency (EMA). Selection criteria: We included systematic reviews, meta-analyses, randomized clinical trials, clinical guidelines focused on acute ischemic stroke and comparing citicoline versus placebo or no intervention. We excluded narrative reviews, observational studies and ongoing trials.
背景：胞磷胆碱是一种治疗缺血性中风的处方药，因其未经证实的疗效和潜在危害而备受关注。本文借鉴了最近的 Cochrane 综述，仅关注全因死亡率，主张对其使用进行批判性的重新评估。本分析不是提供最新的科克伦综述，而是从循证医学和科学哲学的角度提供了一个反思性视角：为什么不应将柠檬胆碱（一种医用食品）用于治疗急性缺血性中风患者？目标：从循证医学和科学哲学的角度证明，由于缺乏有效性和危害的不确定性，柠檬胆碱不应该用于急性缺血性中风的治疗：我们在PubMed和Cochrane图书馆进行了检索，检索时间为2020年至2023年10月30日。此外，我们还使用工程机器 Bing 和 Google Scholar 来检索其他论文。此外，我们还查阅了检索到的出版物和综述文章的参考文献目录，并搜索了美国食品药品管理局（FDA）和欧洲药品管理局（EMA）的网站：我们纳入了系统综述、荟萃分析、随机临床试验、以急性缺血性脑卒中为重点的临床指南，并比较了 citicoline 与安慰剂或无干预措施。我们排除了叙述性综述、观察性研究和正在进行的试验。
{"title":"Why Citicoline (A Medical Food) Should Not be Prescribed to Treat People with Acute Ischemic Stroke: The Certainty of the Evidence","authors":"Prof. Arturo Martí Carvajal, MD, MSc. PhD","doi":"10.34257/ljmhrvol24is2pg19","DOIUrl":"https://doi.org/10.34257/ljmhrvol24is2pg19","url":null,"abstract":"Background: Citicoline, a medical food prescribed for ischemic stroke, faces scrutiny due to itsb unproven ef icacy and potential harms. This essay, drawing on a recent Cochrane review and focusing solely on all-cause mortality, advocates for a critical reevaluation of its use. Rather than of ering an updated Cochrane review, this\u0000analysis provides a reflective perspective through the lens of Evidence-based Medicine and Philosophy of Science.\u0000Question Research: Why citicoline (a medical food) should not be prescribed to treat people with acute ischemic stroke: The certainty of the Evidence.?\u0000Objective: Demonstrate from evidence-based medicine and philosophy of science perspective that citicoline should not be prescribed for acute ischemic stroke due to lack of ef icacy and harm uncertainties.\u0000Search publications: We searched in PubMed and Cochrane Library from 2020 until 30 October 2023. We, furthermore, used engineering machines Bing and Google Scholar to detec additional papers. Additionally, we also reviewed reference lists of the retrieved\u0000publications and review articles and searched the websites of the U. S. Food and Drug\u0000Administration (FDA) and European Medicines Agency (EMA).\u0000Selection criteria: We included systematic reviews, meta-analyses, randomized clinical\u0000trials, clinical guidelines focused on acute ischemic stroke and comparing citicoline versus placebo or no intervention. We excluded narrative reviews, observational studies and ongoing trials.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"70 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140452249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.34257/gjmrjvol23is4pg9
Suveer Sachdeva, Susha Rajadurai
Purpose: COVID-19 mandated emergency remote (online) teaching of dental anatomy at King’s College London. To overcome the challenges of online learning in practical subjects such as dental anatomy, novel approaches to teaching were employed in an attempt to maintain learning quality. Online tutorials were tailored to incorporate technology enhanced learning using digitised lecture slides that emphasised 3-dimensional tooth structures and case-based problem solving along with a key, in-hand, visual aid, namely 1:1 acrylic teeth which were given to each student as a learning accessory. This contemporary online learning format has remained to date. Thus, this work set out to assess the effectiveness of these innovative efforts in online dental anatomy learning and elucidate the key elements that drive learning success. Through this, valuable strategies for improved future course delivery were gained.
{"title":"Innovative Strategies for Dental Anatomy Education: A Qualitative Exploration of Online Learning Perceptions","authors":"Suveer Sachdeva, Susha Rajadurai","doi":"10.34257/gjmrjvol23is4pg9","DOIUrl":"https://doi.org/10.34257/gjmrjvol23is4pg9","url":null,"abstract":"Purpose: COVID-19 mandated emergency remote (online) teaching of dental anatomy at King’s College London. To overcome the challenges of online learning in practical subjects such as dental anatomy, novel approaches to teaching were employed in an attempt to maintain learning quality. Online tutorials were tailored to incorporate technology enhanced learning using digitised lecture slides that emphasised 3-dimensional tooth structures and case-based problem solving along with a key, in-hand, visual aid, namely 1:1 acrylic teeth which were given to each student as a learning accessory. This contemporary online learning format has remained to date. Thus, this work set out to assess the effectiveness of these innovative efforts in online dental anatomy learning and elucidate the key elements that drive learning success. Through this, valuable strategies for improved future course delivery were gained.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"13 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140512788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.34257/gjmrjvol23is4pg1
Flávia Maria Noronha Nigri, L. Aragão, Wildson Max Barbosa da Silva, Guida H.M. do Nascimento, Solange de Oliveira Pinheiro, Juliana Paiva Marques Lima Rolim, D. Cunha, Paulo Goberlânio de Barros Silva, Phillipe Nogueira Barbosa Alencar, J. Neri
Aims: The aim was to evaluate the influence of piperine on the collagen staining and on the degree of conversion of the universal adhesive system applied to the bleached dentin. Methods: The piperine extraction process was carried out using a water reflux system and confirmed by UV-Vis spectrophotometry. For collagen staining analysis, dentin collagen disk were analyzed with a spectrophotometer. Regarding the collagen color evaluation, there was no statistically significant difference between the groups regarding ΔL, Δa, Δb e ΔE (p>0,05). Results: Regarding the degree of conversion, there was no statistically significant difference between without hydrogen peroxide, PH + 0,001% piperine, PH + 0,002% piperine and PH + 0,004% piperine (p>0,05). Conclusions: It is possible to conclude that piperine, did not change the color of the dentin collagen and avoided the reduction in the degree of conversion of a universal adhesive system applied immediately after bleaching with 35% hydrogen peroxide.
{"title":"Influence of Piperine on Collagen Color and Degree of Conversion of a Universal Adhesive System Applied to Bleached Dentin","authors":"Flávia Maria Noronha Nigri, L. Aragão, Wildson Max Barbosa da Silva, Guida H.M. do Nascimento, Solange de Oliveira Pinheiro, Juliana Paiva Marques Lima Rolim, D. Cunha, Paulo Goberlânio de Barros Silva, Phillipe Nogueira Barbosa Alencar, J. Neri","doi":"10.34257/gjmrjvol23is4pg1","DOIUrl":"https://doi.org/10.34257/gjmrjvol23is4pg1","url":null,"abstract":"Aims: The aim was to evaluate the influence of piperine on the collagen staining and on the degree of conversion of the universal adhesive system applied to the bleached dentin. \u0000Methods: The piperine extraction process was carried out using a water reflux system and confirmed by UV-Vis spectrophotometry. For collagen staining analysis, dentin collagen disk were analyzed with a spectrophotometer. Regarding the collagen color evaluation, there was no statistically significant difference between the groups regarding ΔL, Δa, Δb e ΔE (p>0,05). \u0000Results: Regarding the degree of conversion, there was no statistically significant difference between without hydrogen peroxide, PH + 0,001% piperine, PH + 0,002% piperine and PH + 0,004% piperine (p>0,05). \u0000Conclusions: It is possible to conclude that piperine, did not change the color of the dentin collagen and avoided the reduction in the degree of conversion of a universal adhesive system applied immediately after bleaching with 35% hydrogen peroxide.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"16 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140512505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-02DOI: 10.34257/gjmrfvol23is10pg1
Nilufar N. Malikova, K. Karimov, S. Arifov, K. Boboev
Background: The study of the association between acne vulgaris and the TNF-gene polymorphism rs1800629 in the Uzbek population is discussed in this article. Methodology: The research was conducted on 165 patients with various clinical forms of acne vulgaris and 161 healthy donors. Findings: During this research, allele frequencies and genotypes of rs1800629 polymorphism of TNF-α gene were found with statistically significant differences between the control group and subgroups of patients with acne vulgaris. As a result of the investigation, it was discovered that heterozygous genotype G/A should be a genetic marker for an increased risk of acne development, whereas homozygous genotype G/G should be a marker for a reduced risk of acne formation.
{"title":"Polymorphism of Rs1800629 Gene of TNF-Α in the Pathogenesis of Acne Vulgaris","authors":"Nilufar N. Malikova, K. Karimov, S. Arifov, K. Boboev","doi":"10.34257/gjmrfvol23is10pg1","DOIUrl":"https://doi.org/10.34257/gjmrfvol23is10pg1","url":null,"abstract":"Background: The study of the association between acne vulgaris and the TNF-gene polymorphism rs1800629 in the Uzbek population is discussed in this article. Methodology: The research was conducted on 165 patients with various clinical forms of acne vulgaris and 161 healthy donors. \u0000Findings: During this research, allele frequencies and genotypes of rs1800629 polymorphism of TNF-α gene were found with statistically significant differences between the control group and subgroups of patients with acne vulgaris. As a result of the investigation, it was discovered that heterozygous genotype G/A should be a genetic marker for an increased risk of acne development, whereas homozygous genotype G/G should be a marker for a reduced risk of acne formation.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"32 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140515366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: The building and civil engineering sector is a vast one, encompassing a wide range of activities including the construction, repair, renovation and demolition of structures In the course of their activities, workers are subjected to a variety of exposures, including dusts and fumes, asbestos, uncomfortable postures and heavy loads, Methodology: This was a descriptive and analytical cross-sectional study lasting seven (07) months, from November 25, 2020 to June 27, 2021. The city of Conakry served as the setting for the study. The material consisted of workers on construction sites.
{"title":"Profile of Work Accidents in the Building and Public Works Sector BTP about 8 Companies in Conakry","authors":"Habib Toure, Bocar Baila Diedhiou, Cheik amadou Toure, Armandine Eusebia Roseline Diatta","doi":"10.34257/gjmrbvol23is3pg9","DOIUrl":"https://doi.org/10.34257/gjmrbvol23is3pg9","url":null,"abstract":"Introduction: The building and civil engineering sector is a vast one, encompassing a wide range of activities including the construction, repair, renovation and demolition of structures\u0000In the course of their activities, workers are subjected to a variety of exposures, including dusts and fumes, asbestos, uncomfortable postures and heavy loads,\u0000Methodology: This was a descriptive and analytical cross-sectional study lasting seven (07) months, from November 25, 2020 to June 27, 2021.\u0000The city of Conakry served as the setting for the study. The material consisted of workers on construction sites.","PeriodicalId":93101,"journal":{"name":"Global journal of medical research","volume":"24 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140515326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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