Impact of naturopathy and yoga based intervention on atherosclerotic cardiovascular disease risk among metabolic syndrome individuals – A prospective single arm study

Shashikiran HC , Sreegovind R , Krithika A Ramaswamy , Shivaprasad Shetty , Prashanth Shetty
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Abstract

Background

Cardiovascular diseases are the leading cause of death in most developed and developing countries, thus representing one of the most significant health problems across the globe. The association between metabolic syndrome and increased risk of cardiovascular diseases has been proven by large multicentric studies. Calculating atherosclerotic cardiovascular diseases risk has been advocated as a preventive strategy. A little is known about its utility and applicability of atherosclerotic cardiovascular diseases risk calculation in individuals predisposed to cardiovascular diseases such as individuals with metabolic syndrome. Practice of a multifaceted naturopathy and yoga-based lifestyle is likely to improve cardiovascular health outcomes and may reduce healthcare costs in high-risk populations. Hence the present study aimed to evaluate the impact of naturopathy and yoga-based lifestyle intervention on the calculated atherosclerotic cardiovascular diseases risk among metabolic syndrome individuals.

Methods

This prospective single arm study recruited 70 individuals of both genders, with metabolic syndrome based on eligibility criteria. They underwent 10 days of supervised intensive naturopathy and yoga-based lifestyle intervention in a residential center. Blood pressure, Anthropometric measures and metabolic risk factors were assessed before and after the intervention.

Results

There was also a substantial decrease in both systolic blood pressure (p < 0.001) and diastolic blood pressure (p < 0.001) compared to baseline. There was a noteworthy decrease in weight (p < 0.001), Body mass index (p < 0.001), Waist circumference (p < 0.001), Hip circumference (p < 0.001) and Waist Hip Ratio (p = 0.005). The metabolic risk factors Fasting blood glucose (p < 0.001), Total cholesterol (p < 0.001), Triglycerides (p < 0.001), High-density lipoprotein (p < 0.01), Low-density lipoprotein (p < 0.01), Very low-density lipoprotein (p < 0.001), TC/HDL (p < 0.001) and non-HDL (p < 0.001) also showed a significant reduction. The 10-year (p < 0.001) and lifetime risk of atherosclerotic cardiovascular diseases risk was assessed and found to be significantly reduced after the intervention.

Conclusion

A multidimensional intensive naturopathy and yoga-based lifestyle could be explored as a non-invasive and cost-effective measure in the mitigation of atherosclerotic cardiovascular diseases risk in predisposed individuals.

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自然疗法和瑜伽干预对代谢综合征患者动脉粥样硬化性心血管疾病风险的影响——一项前瞻性单臂研究
背景心血管疾病是大多数发达国家和发展中国家的主要死因,因此是全球最严重的健康问题之一。代谢综合征与心血管疾病风险增加之间的相关性已被大型多中心研究所证实。计算动脉粥样硬化性心血管疾病的风险一直被认为是一种预防策略。对其在易患心血管疾病的个体(如代谢综合征患者)中动脉粥样硬化性心血管疾病风险计算的实用性和适用性知之甚少。多方面的自然疗法和瑜伽生活方式可能会改善心血管健康状况,并可能降低高危人群的医疗成本。因此,本研究旨在评估自然疗法和基于瑜伽的生活方式干预对代谢综合征个体动脉粥样硬化性心血管疾病风险的影响。方法这项前瞻性单臂研究招募了70名符合资格标准的代谢综合征患者。他们在一个居住中心接受了为期10天的强化自然疗法和基于瑜伽的生活方式干预。干预前后对血压、人体测量和代谢危险因素进行评估。结果与基线相比,收缩压(p<0.001)和舒张压(p>0.001)也显著降低。体重(p<0.001)、体重指数(p<001)、腰围(p>0.001)、臀围(p<0.01)和腰臀比(p=0.005)显著下降,低密度脂蛋白(p<0.01)、极低密度脂素(p<0.001)、TC/HDL(p<001)和非HDL(p>0.001)也显示出显著降低。对动脉粥样硬化性心血管疾病风险的10年(p<0.001)和终生风险进行了评估,发现在干预后显著降低。结论多维强化自然疗法和以瑜伽为基础的生活方式可以作为一种非侵入性和成本效益高的措施来缓解易感人群动脉粥样硬化性心血管疾病的风险。
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