Survival Outcomes and Patterns of Failure in Maxillary Alveolus Squamous Cell Carcinoma.

IF 1 Q3 OTORHINOLARYNGOLOGY International Archives of Otorhinolaryngology Pub Date : 2023-10-23 eCollection Date: 2023-10-01 DOI:10.1055/s-0042-1758214
Muhammad Umar Qayyum, Ahmed Ali Keerio, Muhammad Faisal, Asma Rashid, Raza Hussain, Arif Jamshed
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Abstract

Introduction  Squamous cell carcinoma (SCC) of the maxillary alveolus is a relatively rare disease. There is lack of data on this subsite as compared with other sites. The factors that affect survival in cases of maxillary alveolar SCC are tumor stage, local and cervical metastases, histological grading, and the margin status. Objectives  To evaluate the overall survival (OS), the disease free survival (DFS), and the complex interaction and effects of margin status, histological differentiation, habits (such as smoking and the use of smokeless tobacco products), and cervical and distant metastases based on clinicopathological data. Methods  We examined the electronic database at our hospital from 2003 to 2017. We included all cases with a histopathological diagnosis of SCC of the maxillary alveolus. Tumors originating primarily from the maxillary alveolus were included, while those originating from adjacent subsites, like the hard palate, the buccal mucosa or the maxillary sinus were excluded. We also excluded all the patients who were not operated on with a curative intent. Results  More than half of the patients had stage-IV tumors at the time of presentation, while only one fourth of them had nodal metastasis. The rate of recurrence increased in cases of primary tumors in advanced stages and the degree of histological differentiation. The 2-year and 5-year OS rates were of 54.5% (18 patients) and 30.3% (10 patients) respectively. Conclusion  Primary tumors in advanced stages, histological grade, and presence of nodal metastasis are poor prognostic markers in terms of long-term survival.

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上颌牙槽鳞状细胞癌的生存结局和失败模式。
介绍 上颌肺泡鳞状细胞癌是一种相对罕见的疾病。与其他网站相比,此子网站缺少数据。影响上颌牙槽SCC患者生存的因素包括肿瘤分期、局部和颈部转移、组织学分级和边缘状态。目标 根据临床病理数据评估总生存率(OS)、无病生存率(DFS)以及边缘状态、组织学分化、习惯(如吸烟和使用无烟烟草制品)以及宫颈和远处转移的复杂相互作用和影响。方法 我们检查了2003年至2017年我院的电子数据库。我们纳入了所有组织病理学诊断为上颌牙槽SCC的病例。主要来源于上颌牙槽的肿瘤被包括在内,而那些来源于相邻亚位点的肿瘤,如硬腭、颊粘膜或上颌窦被排除在外。我们还排除了所有未进行手术治疗的患者。后果 超过一半的患者在出现时患有IV期肿瘤,而只有四分之一的患者有淋巴结转移。晚期原发性肿瘤的复发率和组织学分化程度增加。2年和5年OS发生率分别为54.5%(18例)和30.3%(10例)。结论 晚期原发性肿瘤、组织学分级和是否存在淋巴结转移是长期生存的不良预后标志。
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CiteScore
2.80
自引率
0.00%
发文量
84
审稿时长
12 weeks
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