Ventilatory, phonatory and swallowing impairments in advanced neuromuscular disease patients

Natalia Muñoz-Vigueras, Irene Torres-Sánchez, Paula Obeso-Benitez, Esther Prados-Román, María Granados-Santiago, Irene Cabrera-Martos, Marie Carmen Valenza
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引用次数: 1

Abstract

Purpose

To analyze the ventilatory, phonatory and swallowing impairments and their relation with physical status in a group of advanced Neuromuscular Disease (NMD).

Methods

A cross-sectional observational study was utilized 48 participants from the Association of NMD of Granada (Granada, España), university clinical research, University of Granada. A total of 24 advanced NMD patients and 24 healthy controls matched for age and sex were recruited. Advanced NMD patients were divided in two groups according to the level of their overall physical status (NMD higher physical status group or NMD lower physical status group). Hand grip strength, ventilatory, phonatory and swallowing features were analyzed.

Results

There were significant differences (p < .05) among NMDs groups in ventilatory function. There were significant differences (p < .05) between NMDs groups in ventilatory, phonatory and swallowing function. Finally, there were significant differences (p < .05) among advanced NMDs groups in swallowing function and orofacial evaluation.

Conclusion

Patients with lower physical status have higher risk of suffer ventilatory, phonatory and swallowing complications after diagnosis of NMD.

Registered in the Clinical Trials reference: NCT04473612.

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晚期神经肌肉疾病患者的通气、发声和吞咽障碍
目的分析一组晚期神经肌肉疾病(NMD)患者的通气、发音和吞咽障碍及其与身体状况的关系。共招募了24名晚期NMD患者和24名年龄和性别匹配的健康对照者。晚期NMD患者根据其整体身体状况分为两组(NMD高身体状况组或NMD低身体状况组)。分析了握力、通气、发音和吞咽特点。结果NMDs组通气功能有显著性差异(p<0.05)。NMDs组在通气、发音和吞咽功能方面存在显著差异(p<0.05)。最后,晚期NMD组在吞咽功能和口腔面部评估方面存在显著差异(p<0.05)。结论低体力状态患者在诊断为NMD后发生通气、发音和吞咽并发症的风险较高。临床试验注册号:NCT04473612。
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