{"title":"Synthesis of aliskiren","authors":"Wu Xiaoming","doi":"10.1055/s-0034-1380902","DOIUrl":null,"url":null,"abstract":"This paper describes a practical process for the preparation of aliskiren.Chiral building blocks 1 and 2 were prepared by chemical resolution,and a following five-step convergent synthesis led to aliskiren with an overall yield of 15.6%.The intermediates and the target compound were characterized by melting points,NMR and MS.The convergent synthetic process of aliskiren highlights reasonable yields,ease of operation,high stereoselectivity as well as only one chromatographic purification,and thus should be amenable to large-scale production.","PeriodicalId":15350,"journal":{"name":"中国药科大学学报","volume":"35 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0034-1380902","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国药科大学学报","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.1055/s-0034-1380902","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
引用次数: 0
Abstract
This paper describes a practical process for the preparation of aliskiren.Chiral building blocks 1 and 2 were prepared by chemical resolution,and a following five-step convergent synthesis led to aliskiren with an overall yield of 15.6%.The intermediates and the target compound were characterized by melting points,NMR and MS.The convergent synthetic process of aliskiren highlights reasonable yields,ease of operation,high stereoselectivity as well as only one chromatographic purification,and thus should be amenable to large-scale production.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
