Pub Date : 2021-01-01DOI: 10.11665/j.issn.1000-5048.20210101
R. Wang, Z. Zheng, Y. Zhang, R. Min, Y. Zhu, P. Zhang
Coronavirus is an important pathogen of humans and animals.Among them, the novel coronavirus disease (COVID-19) breaking out in 2019 has brought a fatal threat to human health.The host's innate immune response is the host's first line of defense against pathogen invasion, but an excessive immune response can also aggravate viral infection and pathological damage.The immune escape of coronavirus is a critical pathogenic mechanism causing death.This work mainly reviews the pathogenic mechanism of coronavirus immune escape from several aspects such as host immunosensor, interferon, cytokine and coronavirus antagonizing host immune response, which provide a theoretical reference for the development of anti-coronavirus drugs.
{"title":"Progress of research on immune escape mechanism of coronavirus","authors":"R. Wang, Z. Zheng, Y. Zhang, R. Min, Y. Zhu, P. Zhang","doi":"10.11665/j.issn.1000-5048.20210101","DOIUrl":"https://doi.org/10.11665/j.issn.1000-5048.20210101","url":null,"abstract":"Coronavirus is an important pathogen of humans and animals.Among them, the novel coronavirus disease (COVID-19) breaking out in 2019 has brought a fatal threat to human health.The host's innate immune response is the host's first line of defense against pathogen invasion, but an excessive immune response can also aggravate viral infection and pathological damage.The immune escape of coronavirus is a critical pathogenic mechanism causing death.This work mainly reviews the pathogenic mechanism of coronavirus immune escape from several aspects such as host immunosensor, interferon, cytokine and coronavirus antagonizing host immune response, which provide a theoretical reference for the development of anti-coronavirus drugs.","PeriodicalId":15350,"journal":{"name":"中国药科大学学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64698439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-01DOI: 10.11665/J.ISSN.1000-5048.20170516
Lan-Jie Cao, K. Zhu, Cuihua Jiang, J. Gunn, C. Che, Jian Zhang, Zhiqi Yin
{"title":"Intervention effects of the extract of alismatis rhizoma on streptozotocin-induced type 2 diabetic rats","authors":"Lan-Jie Cao, K. Zhu, Cuihua Jiang, J. Gunn, C. Che, Jian Zhang, Zhiqi Yin","doi":"10.11665/J.ISSN.1000-5048.20170516","DOIUrl":"https://doi.org/10.11665/J.ISSN.1000-5048.20170516","url":null,"abstract":"","PeriodicalId":15350,"journal":{"name":"中国药科大学学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42271788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper describes a practical process for the preparation of aliskiren.Chiral building blocks 1 and 2 were prepared by chemical resolution,and a following five-step convergent synthesis led to aliskiren with an overall yield of 15.6%.The intermediates and the target compound were characterized by melting points,NMR and MS.The convergent synthetic process of aliskiren highlights reasonable yields,ease of operation,high stereoselectivity as well as only one chromatographic purification,and thus should be amenable to large-scale production.
{"title":"Synthesis of aliskiren","authors":"Wu Xiaoming","doi":"10.1055/s-0034-1380902","DOIUrl":"https://doi.org/10.1055/s-0034-1380902","url":null,"abstract":"This paper describes a practical process for the preparation of aliskiren.Chiral building blocks 1 and 2 were prepared by chemical resolution,and a following five-step convergent synthesis led to aliskiren with an overall yield of 15.6%.The intermediates and the target compound were characterized by melting points,NMR and MS.The convergent synthetic process of aliskiren highlights reasonable yields,ease of operation,high stereoselectivity as well as only one chromatographic purification,and thus should be amenable to large-scale production.","PeriodicalId":15350,"journal":{"name":"中国药科大学学报","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0034-1380902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"57971117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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