Brian Goldstein, Dongsoo Kim, A. Rottigni, Jian Xu, T. Vanderlick, E. Culurciello
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引用次数: 64
Abstract
We present a micro-chip implementation of a low current measurement system for biomedical applications using capacitive feedback that exhibits 190 fA of RMS noise in a 1 kHz bandwidth. The sampling rate is selectable up to 100 kHz. When measuring the amplifier noise with a 10 G Ω resistor and a 47 pF capacitor at the input, typical of cell membrane capacitance in DNA and patch clamp experiments, the measured RMS noise was 2.44 pA on a 50 pA signal in a 10 kHz bandwidth. Two channels were implemented on 630 × 440 μm2 using a 0.5- μm 3-metal 2-poly CMOS process. Each channel consumes 1.5 mW of power from a 3.3 V supply. We measured the characteristics of an artificial lipid bilayer similar to the ones used in DNA sequencing experiments via nanopores.
期刊介绍：
The IEEE Transactions on Biomedical Circuits and Systems addresses areas at the crossroads of Circuits and Systems and Life Sciences. The main emphasis is on microelectronic issues in a wide range of applications found in life sciences, physical sciences and engineering. The primary goal of the journal is to bridge the unique scientific and technical activities of the Circuits and Systems Society to a wide variety of related areas such as: • Bioelectronics • Implantable and wearable electronics like cochlear and retinal prosthesis, motor control, etc. • Biotechnology sensor circuits, integrated systems, and networks • Micropower imaging technology • BioMEMS • Lab-on-chip Bio-nanotechnology • Organic Semiconductors • Biomedical Engineering • Genomics and Proteomics • Neuromorphic Engineering • Smart sensors • Low power micro- and nanoelectronics • Mixed-mode system-on-chip • Wireless technology • Gene circuits and molecular circuits • System biology • Brain science and engineering: such as neuro-informatics, neural prosthesis, cognitive engineering, brain computer interface • Healthcare: information technology for biomedical, epidemiology, and other related life science applications. General, theoretical, and application-oriented papers in the abovementioned technical areas with a Circuits and Systems perspective are encouraged to publish in TBioCAS. Of special interest are biomedical-oriented papers with a Circuits and Systems angle.
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