A CMOS Amperometric System for Multi-Neurotransmitter Detection

IF 3.8 2区医学 Q2 ENGINEERING, BIOMEDICAL IEEE Transactions on Biomedical Circuits and Systems Pub Date : 2016-01-08 DOI:10.1109/TBCAS.2015.2490225

G. Massicotte, S. Carrara, G. Micheli, M. Sawan

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引用次数: 18

Abstract

In vivo multi-target and selective concentration monitoring of neurotransmitters can help to unravel the brain chemical complex signaling interplay. This paper presents a dedicated integrated potentiostat transducer circuit and its selective electrode interface. A custom 2-electrode time-based potentiostat circuit was fabricated with 0.13 μm CMOS technology and provides a wide dynamic input current range of 20 pA to 600 nA with 56 μW, for a minimum sampling frequency of 1.25 kHz. A multi-working electrode chip is functionalized with carbon nanotubes (CNT)-based chemical coatings that offer high sensitivity and selectivity towards electroactive dopamine and non-electroactive glutamate. The prototype was experimentally tested with different concentrations levels of both neurotransmitter types, and results were similar to measurements with a commercially available potentiostat. This paper validates the functionality of the proposed biosensor, and demonstrates its potential for the selective detection of a large number of neurochemicals.

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一种用于多神经递质检测的CMOS安培系统

体内多靶点和选择性的神经递质浓度监测有助于揭示大脑化学复合物信号的相互作用。本文介绍了一种专用的集成恒电位器电路及其选择电极接口。采用0.13 μm CMOS工艺制作了一种定制的2电极时基恒电位器电路，其动态输入电流范围为20 pA ~ 600 nA，功率为56 μW，最小采样频率为1.25 kHz。采用基于碳纳米管(CNT)的化学涂层对多工作电极芯片进行功能化，该涂层对电活性多巴胺和非电活性谷氨酸具有高灵敏度和选择性。该原型在两种神经递质类型的不同浓度水平下进行了实验测试，结果与市售的恒电位器测量结果相似。本文验证了所提出的生物传感器的功能，并展示了其选择性检测大量神经化学物质的潜力。

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来源期刊

IEEE Transactions on Biomedical Circuits and Systems 工程技术-工程：电子与电气

CiteScore

10.00

自引率

13.70%

发文量

174

审稿时长

3 months

期刊介绍： The IEEE Transactions on Biomedical Circuits and Systems addresses areas at the crossroads of Circuits and Systems and Life Sciences. The main emphasis is on microelectronic issues in a wide range of applications found in life sciences, physical sciences and engineering. The primary goal of the journal is to bridge the unique scientific and technical activities of the Circuits and Systems Society to a wide variety of related areas such as: • Bioelectronics • Implantable and wearable electronics like cochlear and retinal prosthesis, motor control, etc. • Biotechnology sensor circuits, integrated systems, and networks • Micropower imaging technology • BioMEMS • Lab-on-chip Bio-nanotechnology • Organic Semiconductors • Biomedical Engineering • Genomics and Proteomics • Neuromorphic Engineering • Smart sensors • Low power micro- and nanoelectronics • Mixed-mode system-on-chip • Wireless technology • Gene circuits and molecular circuits • System biology • Brain science and engineering: such as neuro-informatics, neural prosthesis, cognitive engineering, brain computer interface • Healthcare: information technology for biomedical, epidemiology, and other related life science applications. General, theoretical, and application-oriented papers in the abovementioned technical areas with a Circuits and Systems perspective are encouraged to publish in TBioCAS. Of special interest are biomedical-oriented papers with a Circuits and Systems angle.