{"title":"Analysis of disordered regions in protein kinase subfamilies of Homo sapiens and Coenorhabditis elegans","authors":"K. Kurup, J. Natarajan","doi":"10.1145/1722024.1722028","DOIUrl":null,"url":null,"abstract":"Protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them. In this work, first the protein kinases of Coenorhabditis elegans and Homo sapiens with three or more common domain were grouped and disorder regions of protein kinases in each group were predicted. Then the similarities of the disordered regions among the organisms were found. Linear motifs present in these similar disorder regions were identified and tested for their conservation in both Homo sapiens and Coenorhabditis elegans. It is found that, though the similarities in disorder regions are high, the linear motifs are not conserved much in these distantly related organisms.","PeriodicalId":39379,"journal":{"name":"In Silico Biology","volume":"1 1","pages":"3"},"PeriodicalIF":0.0000,"publicationDate":"2010-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1145/1722024.1722028","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"In Silico Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1145/1722024.1722028","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them. In this work, first the protein kinases of Coenorhabditis elegans and Homo sapiens with three or more common domain were grouped and disorder regions of protein kinases in each group were predicted. Then the similarities of the disordered regions among the organisms were found. Linear motifs present in these similar disorder regions were identified and tested for their conservation in both Homo sapiens and Coenorhabditis elegans. It is found that, though the similarities in disorder regions are high, the linear motifs are not conserved much in these distantly related organisms.
In Silico BiologyComputer Science-Computational Theory and Mathematics
CiteScore
2.20
自引率
0.00%
发文量
1
期刊介绍：
The considerable "algorithmic complexity" of biological systems requires a huge amount of detailed information for their complete description. Although far from being complete, the overwhelming quantity of small pieces of information gathered for all kind of biological systems at the molecular and cellular level requires computational tools to be adequately stored and interpreted. Interpretation of data means to abstract them as much as allowed to provide a systematic, an integrative view of biology. Most of the presently available scientific journals focus either on accumulating more data from elaborate experimental approaches, or on presenting new algorithms for the interpretation of these data. Both approaches are meritorious.
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