Amit Nagal, Swapnil R. Jaiswal, H. Yadav, M. Mohan, P. Ghosh
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引用次数: 0
Abstract
There are many Drug used in the treatment of inflammation disease like NSAIDS but there limitation encouraging more research in inflammatory related diseases. Phospholipases A2 (PLA2s) are enzymes that catalyze the hydrolysis of the sn-2 acyl ester linkage of phospholipids, producing fatty acids and lysophospholipids. Their enzymatic activity is a rate-limiting step in the formation of arachidonic acid and subsequently in the synthesis of leukotrienes and prostaglandins. The current Structure Based Drug Designing approach analysis and comparative docking studies of various hnps-PLA2 indole inhibitor derivatives have shown that they act better in compare with other molecules. ADME studies shows that indole derivatives would be potential of being a safe drug
In Silico BiologyComputer Science-Computational Theory and Mathematics
CiteScore
2.20
自引率
0.00%
发文量
1
期刊介绍：
The considerable "algorithmic complexity" of biological systems requires a huge amount of detailed information for their complete description. Although far from being complete, the overwhelming quantity of small pieces of information gathered for all kind of biological systems at the molecular and cellular level requires computational tools to be adequately stored and interpreted. Interpretation of data means to abstract them as much as allowed to provide a systematic, an integrative view of biology. Most of the presently available scientific journals focus either on accumulating more data from elaborate experimental approaches, or on presenting new algorithms for the interpretation of these data. Both approaches are meritorious.
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