Clinical characteristics of patients with COVID-19 combined with cardiovascular disease

Abstract

Objective: To retrospectively analyze the clinical characteristics of coronavirus disease 2019 (COVID-19) and the impact of cardiovascular disease (CVD) on the clinical manifestations of COVID-19. Methods: A total of 128 patients diagnosed with COVID-19 in Renmin Hospital of Wuhan University from February 1 to February 29, 2020 were divided into CVD group (n=62) and non-CVD group (n=66). The general data, admission symptoms and laboratory examination results including blood routine, immunity, heart, liver and kidney function were obtained and statistically analyzed by SPSS 22.0 statistical software. The differences of various indexes between CVD group and non-CVD group were compared. Results: There was no significant difference in gender between CVD group and non-CVD group(P>0.05).The average age of CVD group was higher than that of non-CVD group (P 0.05). The average levels of eukocyte count, neutrophil ratio, neutrophil count, monocyte count, and C-reactive protein in CVD group were higher than those in non-CVD group (all P 0.05). The average LDH, myohemoglobin, CK-MB, NT-proBNP, TBIL, and Urea in CVD group were higher than those in non-CVD group (all P 0.05). Conclusion: Compared with non-CVD patients with COVID-19, CVD patients with COVID-19 are older, have more obvious symptoms, with a higher risksin heart, liver, and kidney injury, but the mechanism is not clear yet. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.