C. Ikese, S. T. Ubwa, S. Adoga, S. Audu, M. I. Kuleve, F. O. Okita, A. Okoh
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引用次数: 0
Abstract
The bioactive ingredients in most malarial drugs only reduce plasmodium load during chemotherapy. No anti-malarial drug replenishes the red blood cells destroyed by Plasmodium. This creates a need to incorporate bioactive components with haematinic property in malaria therapy. This study aimed to assess the effect of T. occidentalis leaf extract on packed cell volume (PCV) of rats with malaria-induced anaemia. Anaemia was induced in the rats by inoculating them with Plasmodium berghei. The effect of the plant extract on the PCV of the rats was determined alongside a negative and a positive control. Also, the effect of varying doses of the extract on PCV of the rats was determined. T. occidentalis leaf extract produced a 22 % increase in the post-inoculation PCV of rats. The negative and positive control groups showed a 37 % and 25 % decrease, respectively, in PCV. Also, PCV increased with increase in extract dose administered.
期刊介绍：
Original work in all branches of chemistry is published in the South African Journal of Chemistry. Contributions in English may take the form of papers, short communications, or critical reviews.
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