{"title":"Dietary control of low-grade chronic inflammation by correcting gut microbiota","authors":"A. Khavkin, V. Novikova, N. Evdokimova","doi":"10.20953/1727-5784-2022-1-32-41","DOIUrl":null,"url":null,"abstract":"This review focuses on the interaction between the microbiota and macroorganism in conditions of biological equilibrium, which is the basis of maintaining human homeostasis in general. Low-grade chronic inflammation (LGCI) is realized within this interaction in dysbiosis of various genesis. Bacterial endotoxins are normally the final effectors of LGCI, which are involved in the maturation of the immune system’s components, further determining its ability to neutralize and eliminate pathogens. However, altered intestinal permeability with subsequent microbial translocation to unrelated epitopes may cause LGCI. The review presents several possible options for affecting the gut microbiota and thus LGCI: through the use of probiotics, prebiotics, restrictive diets, and fermented probiotic food products. Key words: diet, probiotics, prebiotics, gut microbiota, low-grade chronic inflammation","PeriodicalId":53444,"journal":{"name":"Voprosy Detskoi Dietologii","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Voprosy Detskoi Dietologii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20953/1727-5784-2022-1-32-41","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
This review focuses on the interaction between the microbiota and macroorganism in conditions of biological equilibrium, which is the basis of maintaining human homeostasis in general. Low-grade chronic inflammation (LGCI) is realized within this interaction in dysbiosis of various genesis. Bacterial endotoxins are normally the final effectors of LGCI, which are involved in the maturation of the immune system’s components, further determining its ability to neutralize and eliminate pathogens. However, altered intestinal permeability with subsequent microbial translocation to unrelated epitopes may cause LGCI. The review presents several possible options for affecting the gut microbiota and thus LGCI: through the use of probiotics, prebiotics, restrictive diets, and fermented probiotic food products. Key words: diet, probiotics, prebiotics, gut microbiota, low-grade chronic inflammation
期刊介绍:
The scientific journal Voprosy Detskoi Dietologii is included in the Scopus database. Publisher country is RU. The main subject areas of published articles are Food Science, Pediatrics, Perinatology, and Child Health, Nutrition and Dietetics, Клиническая медицина.