Duration of anti-tissue transglutaminase normalization after starting a gluten-free diet in children with celiac disease

S. M. Dehghani, M. Anbardar, I. Shahramian, M. Arán, S. Hamzeloo, F. Fazeli, S. Rakhshaninasab, M. Tahani
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Abstract

The aim of the present study was to investigate the time required for the normalization of anti-tissue transglutaminase antibodies IgA (anti-TTG IgA) after starting a gluten-free diet (GFD) in children with celiac disease (CeD). This study included 59 children under 18 years of age with a confirmed diagnosis of CeD referred to Imam Reza Clinic affiliated with Shiraz University of Medical Sciences. All children were divided into two groups, including those with either <180 or >180 U/mL anti-TTG IgA levels. The titer of anti-TTG IgA was checked after the start of GFD. Data analysis was performed using a SPSS software (version 21). The shortest time of anti-TTG IgA normalization was acquired three months after the start of GFD, while the longest time was 30 months. The total average time of normalization was 12.28 ± 6.48 months. The average periods of normalization in patients with baseline anti-TTG IgA titers of <180 and >180 U/mL were 11.30 ± 6.12 and 13.82 ± 6.86 months, respectively (P > 0.05). According to our results, the duration for normalization of anti-TTG IgA levels after GFD initiation was independent of the baseline antibody titer at the time of diagnosis. Key words: normalization time, transglutaminase, gluten-free diet, celiac disease.
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乳糜泻儿童开始无麸质饮食后抗组织转谷氨酰胺酶正常化的持续时间
本研究的目的是调查乳糜泻(CeD)患儿开始无麸质饮食(GFD)后抗组织转谷氨酰胺酶抗体IgA(抗ttg IgA)正常化所需的时间。本研究包括59名18岁以下确诊为CeD的儿童,转至设拉子医科大学附属伊玛目礼萨诊所。所有儿童分为两组,包括抗ttg IgA水平为180 U/mL的儿童。GFD开始后检测抗ttg IgA滴度。数据分析使用SPSS软件(版本21)进行。抗ttg IgA正常化时间最短的是在GFD开始后3个月,最长的是30个月。总平均正常化时间为12.28±6.48个月。基线抗ttg IgA滴度为180 U/mL的患者平均恢复正常周期分别为11.30±6.12和13.82±6.86个月(P < 0.05)。根据我们的结果,GFD启动后抗ttg IgA水平正常化的持续时间与诊断时的基线抗体滴度无关。关键词:正常化时间,谷氨酰胺转胺酶,无谷蛋白饮食,乳糜泻。
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来源期刊
Voprosy Detskoi Dietologii
Voprosy Detskoi Dietologii Medicine-Pediatrics, Perinatology and Child Health
CiteScore
1.20
自引率
0.00%
发文量
17
期刊介绍: The scientific journal Voprosy Detskoi Dietologii is included in the Scopus database. Publisher country is RU. The main subject areas of published articles are Food Science, Pediatrics, Perinatology, and Child Health, Nutrition and Dietetics, Клиническая медицина.
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